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Saturated fat in diet and post-treatment PSA failure

Posted Sep 29 2008 4:46pm

A few weeks ago, Strom et al. reported an apparent association between the amount of saturated fat in patients’ diets following treatment for localized disease and their risk for biochemical failure. This report just came to our attention. However, it is a retrospective analysis of historic data and therefore needs to be interpreted with some caution.

The authors evaluated the association between saturated fat intake and biochemical failure among 390 men from a previously described group of radical prostatectomy patients. Participants had completed a food frequency questionnaire for the year prior to diagnosis.

During a mean follow-up of 70.6 months, 78/390 men (20 percent) experienced biochemical failure. Men who consumed highly saturated fat diets were more likely to experience biochemical failure and had shorter times to biochemical progression than men who ate low saturated fat diets (26.6 vs. 44.7 months). Men who were both obese and consumed high saturated fat diets had the shortest times to biochemical failure (average 19 months), and non-obese men who consumed low saturated fat diets had the longest times to biochemical failure (average 46 months).

It sounds like there’s a lesson here, but we probably need more information to be sure.

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