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Platelets Up , Tacro Down

Posted Feb 21 2009 11:36pm
Day +44 (D 182)

I have been trying to figure out a better way to post Ann's blood counts from the CBCs (Complete Blood Counts) we get on clinic days. After doing this for officially just over half a year now, it is still awkward to construct a sentence that covers the counts, or jam them into an existing one. So to fix the problem I'm just going to table them, like so for today's counts...

WBC 4.80 K/uL (4.0 - 11.0)
ANC 3.43 K/uL (1.7 - 7.3)
RBC 2.74 K/uL (4.0 - 5.0)
HGB 8.81 G/dL (12.0 - 16.0)
PLT 86.0 K/uL (140 - 440)

The left numbers are Ann's current counts and the numbers on the right are the normal range. Now it's much easier to point out what is going on. Ann's WBC and ANC counts are in the normal range, so she continues to be free of Neupogen injections. The RBC and Hemoglobin fronts are still lagging, and probably will for the next two months or so. However, the rate at which her HGB numbers decline has begun to slow down. The star of today's numbers however has got to be the platelets. Tuesday they were at 33K, then on Friday they jumped to 61K and today they are at 86K which is a little over half way to normal.

To put it in the words of Ann's Doctor "We hit a triple": No transplant problems, Good engraftment and no GvHD so far. He seems to be cautiously positive about Ann's results so far, but he did note that we have a long way still to go. Our next sign post will be another Bone Marrow Biopsy at day +90. I'm already biting my nails.

One change that has been made is that Ann's dose of Tacrolimus (or Prograf)the main medicine that is being used to prevent GvHD has been reduced from 1 mg twice a day to 0.5 mg twice a day. The Pharm D that made the change said that this is a pretty routine shift due to tacro building up in people's systems pretty easily. They don't expect the reduction to invite the onset of GvHD.

In other news we have officially finished the move from one apartment to the other and it feels great to finally have some time off. Finished cleaning the old apartment and dropped off the keys just before setting down to type this. The rest of the weekend will be spent unpacking everything and finding places for everything to go.

One more piece of MDA related news seems that M. D. Anderson has been rated the number one cancer treatment institution in the country by U.S. News and World Report. I never ever thought I would have a reason to be happy about being in Texas!
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