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Osteocalcin and bone metastases

Posted Oct 04 2009 11:12pm

Osteocalcin is a noncollagenous protein found in bone and dentin. It is secreted by osteoblasts and thought to play a role in mineralization and calcium ion homeostasis. It As osteocalcin is manufactured by osteoblasts, it is often used as a biochemical marker, or biomarker, for the bone formation process. Most of the use has been for monitoring treatment for osteoporosis but some use it for following metastatic bone disease. There are no guideline or consensus recommendations supporting this test for routine use.

Seregni E, Martinetti A, Ferrari L, et al: Clinical utility of biochemical marker of bone remodelling in patients with bone metastases of solid tumors. Q J Nucl Med 2001; 45(1):7-17.

Brown JP, Josse RG, & Scientific Advisory Council of the Osteoporosis Society of Canada: 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. CMAJ 2002; 167(10 Suppl):S1-S34.

Yoichi Arai et al, Osteocalcin: Is it a useful marker of bone metastasis and response to treatment in advanced prostate cancer? The Prostate Volume 20 Issue 3, Pages 169 - 177

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