New therapeutic approaches for small cell lung cancer
Posted Dec 13 2009 12:00am
I am currently working on a project with our lung cancer research group at Rush University Medical Center in Chicago in which we are looking at expression of the BCL-2 family protein, MCL-1. MCL-1 is interesting because it can either be anti- or pro-apoptotic depending on alternative splicing. So I was interested in this nice review article that explores the role of novel targeted agents in SCLC. This article specifically discusses agents targeting the bcl-2 protein family. The prognosis for SCLC remains pretty dismal but there is a lot of interest in this malignancy because of the better understanding of pathways involved in SCLC and the development of "targeted" therapies.