A friend (thank you!) sent me an MD Anderson study published in Blood (see abstract: http://tinyurl.com/2l4hb3) in July 2007. The study informs us that Salinosporamide A, a powerful proteasome inhibitor extracted from a marine bacterium, Salinispora tropica, also suppresses NF-kappa B, inhibits RANKL-induced osteoclastogenesis, and can overcome MM cell resistance to bortezomib (Velcade). The latter [...]
A friend (thank you!) sent me an MD Anderson study published in Blood (see abstract: http://tinyurl.com/2l4hb3) in July 2007. The study informs us that Salinosporamide A, a powerful proteasome inhibitor extracted from a marine bacterium, Salinispora tropica, also suppresses NF-kappa B, inhibits RANKL-induced osteoclastogenesis, and can overcome MM cell resistance to bortezomib (Velcade). The latter [...]