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Is Weight Loss Surgery Enhances The Risk Of Colon Cancer?

Posted Apr 11 2013 12:13pm

Being overweight is already connected to high chance of digestive tract or anal melanoma, but a new research indicates this danger is even greater for overweight individuals who have gone through weight-loss surgery treatment. Based on a research of more than 77,000 overweight sufferers, Swedish and English scientists discovered the danger for intestinal tract melanoma among those who have had obesity surgery treatment is double that of the common inhabitants. Though intestinal tract melanoma risk among overweight sufferers who didn't have the surgery treatment was just 26 % greater than in the common inhabitants, scientists said the outcomes should not discouraget individuals from going under the knife.

 "These results should not be used to guide decisions made by sufferers or physicians at all until the outcomes are verified by other research," said Dr. Jesper Lagergren, the new study's senior author and a professor at both the Karolinska Institute in Stockholm and King's College London.
Each season more than 100,000 individuals in the U.S. have done surgery treatment to cure obesity.Lagergren and his co-workers point out in their report, released in the Annals of Surgery, that obesity is connected with raised threats for a variety of malignancies, such as intestinal tract, breasts and prostate.

Whether colon cancer treatment to shed bodyweight can impact those threats is unclear.Two previously research, one from the U.S. and the other from Sweden, discovered that the chances of obesity-related malignancies decrease after females have weight-loss surgery treatment.
But an earlier research from Lagergren's team discovered the threats for breasts and prostate malignancies were unchanged by obesity surgery treatment, and intestinal tract melanoma risk increased.

To examine that finding further, Lagergren's team gathered 29 years' worth of medical records on more than 77,000 individuals in Sweden who were clinically diagnosed as overweight between 1980 and 2009. About 15,000 of them experienced weight-loss surgery treatment. In the surgery group, 70 individuals designed colon cancer - a rate that was 60 % greater than what would be predicted for the larger Swedish population.When the scientists looked only at individuals who had surgery treatment more than 10 year before the end of the research period, the variety of melanoma cases was 200 % greater than the predicted risk for the general population.

In comparison, 373 individuals in the no-surgery team developed intestinal tract melanoma, which was 26 % more than would be predicted in the inhabitants and that variety stayed constant over time.
A two-foldincreased risk for intestinal tract melanoma is not a "negligible risk increase, but it should not be of any major concern for the individual patient since the overall danger is still low," Lagergren told Reuters Health in an email.

In the U.S., for example, 40 out of every 100,000 females and approximately 53 out of every 100,000 men develop intestinal tract melanoma each season.
Doubling that danger would make the yearly numbers 80 out of every 100,000 females and 106 out of every 100,000 men.
Lagergren said that more research are needed to validate his outcomes before they should be included in medical decision-making about whether sufferers should go through weight-loss surgery treatment.

The research outcomes cannot confirm that the surgery treatment is the cause of the raised cancer risk. And, Lagergren says it's also not clear why the surgery treatment might be connected with an raised chance of intestinal tract melanoma. One probability is that nutritional changes after surgery treatment, and increasing protein in particular, could raise melanoma danger, he believed. Because the gut performs a significant role in the defense mechanisms, he added, "Another potential factor is that the parasites that normally live in the digestive system may change after surgery treatment and after surgery and alter future cancer risk."
Lagergren mentioned that he also couldn't rule out the  possibility that residual excess weight and weight gain after surgery might be involved.

Source: Annals of Surgery

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