Thought I'd put together a few trivia questions for those of you who want to test your hairy cell leukemia knowledge Questions1) What type of cells are hairy cells believed to come from? 2) Who discovered hairy cell leukemia? 3) In what year was it discovered? 4) Where was the discovery made? 5) What is the formal name of hairy cell leukemia? 6) What protein is overexpressed on hairy cells and the main target of monoclonal antibody therapy? 7) What does the "CD" in "CD20" stand for? 8) Name the primary chemotherapies for hairy cell leukemia? 9) When is Pentostatin typically used in lieu of Cladribine? 10) What's the term for treatment with a monoclonal antibody (mAb)? 11) What is the primary mAb used to treat hairy cell? 12) What other surface proteins are also targeted in hairy cell? 13) Name a well known HCL immunotoxin? 14) Who is Ira Paston ? 15) What is the bacterial toxin used in HA22, and what it's origin? 16) What is the typical cause of fever after treatment with Cladribine (commonly misdiagnosed as "a mystery infection")? 17) What are the three modes of cell death mediated by Rituxan? 18) Who invented Cladribine? 19) Which is the more effective approach for administering Cladribine? 5 day x 2 hour IV or 24x7 drip? 20) At what stage of cellular development is the malignant mutation of hairy cell believed to occur? 21) What is the median age of an HCL patient? 22) Is HCL more prevalent in men or women? 23) What causes HCL? 24) What is the average period of remission for HCL after Cladribine chemotherapy? 25) What percentage of patients receiving Cladribine have a complete remission, partial remission, and no response? 26) How rare is HCL? 27) What does MRD stand for?
Answers1) B-cells, a type of lymphocyte. 2) Bertha A. Bournoncle, MD 3) 1958 4) Ohio State University 5) Reticuloendotheliosis 6) CD20 7) "Cluster of Differentiation" 8) Cladribine and Pentostatin 9) When a patient's counts are so low or health is so weak that a less sudden drop in counts is needed; however, it is sometimes used if a patient doesn't respond to Cladribine. Pentostatin is administered over several weeks whereas Cladribine is administered in 5 or 7 days. 10) mAb therapy 11) Rituximab (aka: Rituxan) 12) CD25, CD22 13) HA22 14) Head of NIH laboratory of molecular biology and immunotoxin development 15) Pseudomonas Exotoxin from Pseudomonas aeruginosa 16) Tumor Lysis (hairy cells dying) 17) Apoptosis (cell suicide), antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC) 18) Dr. Dennis Carson 19) Both are considered equally effective 20) Later in the differentiation process at the level of the germinal center B-cells, likely in the process of differentiating to a Memory B-cell ( per Basso, et al , p.62, col 1). 21) 52 22) Men, by a ratio of 4:1 23) The cause of HCL is yet to be determined. 24) Ten years. 25) 80%, 15% and 5% respectively. 26) HCL accounts for only 2% of diagnosed/reported cases of leukemia. However, it may be more prevelant since it can remain "in-check" in many people without ever being diagnosed. 27) Minimal Residual Disease.