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Gene expression profile for breast cancer responders to AI

Posted Mar 09 2009 12:00am

Interesting article from J Clin Oncol looking at gene expression profiles in breast cancer patients responsive and resistant to the aromatase inhibitor letrozole.  Of note is that tumor specimens were analyzed before and 10-14 days after treatment.  I wonder if a new paradigm is emerging where breast cancers are not excised immediately after diagnosis but following sequential sampling after a variety of medical therapies.  Surgery would be viewed then as a "last resort" for those tumors which are unresponsive to hormonal or other therapies.

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