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Gene expression in NSCLC still work in progress

Posted Mar 19 2010 1:26pm

Gene Expression-Based Prognostic Signatures For NSCLC May Not Yet Be Clinically Useful.HealthDay (3/18, Dotinga) reported that after reviewing "16 studies from 2002 to 2009 that examined the use of gene expression-based prognostic signatures for non-small-cell lung cancer," researchers at the National Cancer Institute "contend that the signatures aren't ready for prime time." According to their paper in the Journal of the National Cancer Institute, "many of the studies did not explain how they're beneficial, and none showed that gene expression signature is an improvement over known risk factors." Investigators "also reported flaws in the studies' design, analysis and validation of data."

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