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Fludarabine and Rituxan

Posted Jul 13 2010 7:25pm

Fludarabine has been  major advance for CLL, alone or in combinations. Despite the observed success with fludarabine, only 20% of previously untreated CLL patients on fludarabine alone attain a CR, and virtually all of these patients eventually experience a relapse. One of the newer combinations is with Rituxan and it is NCCN recommended both for follicular lymphom and CLL in first line. Many new combinations that build on teh success of this regimens are being tested or already been widely adopted, among the latter is the FCR regimen: Fludara, Cytoxan adn Rituxan.

L. Castagna, B. Sarina, A. Santoro, J. C. Byrd, K. Rai, and R. A. Larson
Fludarabine plus rituximab for untreated B-cell chronic lymphocytic leukemia
Blood, September 15, 2003; 102(6): 2309 - 2310.

Byrd JC, Peterson BL, Morrison VA, et al: Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: Results from Cancer and Leukemia Group B 9712 (CALGB 9712). Blood 101:6–14, 2003

C. S. Tam and J. F. Seymour
The infectious consequences of rituximab addition to fludarabine-containing regimens.
Blood, April 1, 2006; 107(7): 3013 - 3014.

M.S. Czuczman, A. Koryzna, A. Mohr, C. Stewart, K. Donohue, L. Blumenson, Z.P. Bernstein, P. McCarthy, A. Alam, F. Hernandez-Ilizaliturri, et al.
Rituximab in Combination With Fludarabine Chemotherapy in Low-Grade or Follicular Lymphoma
J. Clin. Oncol., February 1, 2005; 23(4): 694 - 704.

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