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Cycle #5 Results - RVDD Continues to Dominate

Posted Jan 29 2010 12:00am
For those who just started following, I have been on a clinical trial to dominate Multiple Myeloma using a four drug combination known as RVDD (Revlimid, Velcade, Doxil, Dex). From what I read and hear the most common protocol these days for newly diagnosed MM patients is RVD (no Doxil). The MMRF funded trial that I am on throws the more old school Doxil into the mix and the results from the 60+ patient study has concluded that everyone has had at least a Good Partial Response (50% reduction in the disease).

After Cycle #5, I still haven't achieved Very Good Partial Response (90% reduction), but my numbers are still looking solid and all of my numbers are trending in the right direction. Here they are in Non-Dorky bullet-ed form:
  • M Protein was 0.8, now 0.7 [Normal Range: Zero]
  • IgG was 1120, it's now 806 [Normal Range: 620-1520]
  • Kappa free light was 10.6, now 8.2. [Normal Range: 0.33-1.94]
  • Total Protein was 6.6, now 6.5 [Normal Range: 6.0-8.3]


Here is the data in my preferred dorky excel format for M Protein and IgG respectively:





Given the continued success based on my body's response to the chemo, it has been determined that I will move forward with a 7th round of RVDD after the current cycle I am on. The maximum number of cycles is 8, so there is an end in sight. If I end up with 8 cycles, the only issue we run into is that my transplant may coincide with the birth of Child #3. I guess the good news is the delivery room and the transplant recovery room are all connected!
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