Cold Spring Harbor study shows how “bookmarking” genes before cell division accelerates their subsequent reactivatio
Posted Oct 12 2011 10:23pm
Cold Spring Harbor study shows how “bookmarking” genes before cell division accelerates their subsequent reactivation:NCI Cancer Center News
In order for cells of different types to maintain their identities even after repeated rounds of cell division, each cell must “remember” which genes were active before division and pass along that memory to its daughter cells. Cells deal with this challenge by deploying a “bookmarking” process... This bookmark, the [Cold Spring Harbor Laboratory] scientists show, is a histone molecule that has undergone a chemical modification called acetylation, which alters its interactions with DNA as well as with proteins that bind to it.
Among the research institutions NCI funds across the United States, it currently designates 66 as Cancer Centers. Largely based in research universities, these facilities are home to many of the NCI-supported scientists who conduct a wide range of intense, laboratory research into cancer’s origins and development. The Cancer Centers Program also focuses on trans-disciplinary research, including population science and clinical research. The centers’ research results are often at the forefront of studies in the cancer field.