Metastatic cervical cancer responds moderately to chemotherapy and it can provide palliation. One guideline writes: "It is recommended that all patients, particularly those who have been previously treated with cisplatin as a radiosensitizer, be offered the opportunity to participate in randomized trials, if available, that evaluate the efficacy and toxicity of other single-agent or combination chemotherapy regimens. Until further evidence becomes available, it is recommended that cisplatin in combination with topotecan should be offered to patients on the basis of improvements in response and survival outcomes when compared with single-agent cisplatin alone." However NCCN is more liberal, lisitng in addition carboplatin and cisplatin/paclitaxel, cisplatin/gemcitabine and a variety of single agents. There are no FDA approved chemotherapy drugs specifically for cervical cancer.
Hirte H, Strychowsky J, Oliver T, Fung-Kee-Fung M, Elit L, Oza A, Gynecology Cancer Disease Site Group. Chemotherapy for recurrent, metastatic, or persistent cervical cancer: a clinical practice guideline. Toronto (ON): Cancer Care Ontario (CCO); 2006 Jul 5. 21 p. (Evidence-based series; no. 4-20). [27 references]
Metastatic cervical cancer responds moderately to chemotherapy and it can provide palliation. One guideline writes: "It is recommended that all patients, particularly those who have been previously treated with cisplatin as a radiosensitizer, be offered the opportunity to participate in randomized trials, if available, that evaluate the efficacy and toxicity of other single-agent or combination chemotherapy regimens.
Until further evidence becomes available, it is recommended that cisplatin in combination with topotecan should be offered to patients on the basis of improvements in response and survival outcomes when compared with single-agent cisplatin alone." However NCCN is more liberal, lisitng in addition carboplatin and cisplatin/paclitaxel, cisplatin/gemcitabine and a variety of single agents. There are no FDA approved chemotherapy drugs specifically for cervical cancer.
Hirte H, Strychowsky J, Oliver T, Fung-Kee-Fung M, Elit L, Oza A, Gynecology Cancer Disease Site Group. Chemotherapy for recurrent, metastatic, or persistent cervical cancer: a clinical practice guideline. Toronto (ON): Cancer Care Ontario (CCO); 2006 Jul 5. 21 p. (Evidence-based series; no. 4-20). [27 references]
nccn.org, cervical cancer, p.15