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Avastin for radiation necrosis

Posted Dec 23 2009 7:51am

Avastin si an anti-angiogenic agent and a natural cadidate for blocking vascular endothelial growth factor (VEGF) that produces leaky capillaries which are largely responsible for the edema and symptoms of radiation necrosis in teh brain. A number of case reports and series have been published. However, more studies are clearly needed. A recent series notes: " In children with pontine gliomas, bevacizumab may provide both therapeutic benefit and diagnostic information. More formal evaluation of bevacizumab in these children is needed." Another one concludes: "Bevacizumab, alone and in combination with other agents, can reduce radiation necrosis by decreasing capillary leakage and the associated brain edema. Our findings will need to be confirmed in a randomized trial to determine the optimal duration of treatment."

Gonzalez J, Kumar AJ, Conrad CA, Levin VA.
Effect of bevacizumab on radiation necrosis of the brain.
Int J Radiat Oncol Biol Phys. 2007 Feb 1;67(2):323-6.

Liu AK, Macy ME, Foreman NK.Bevacizumab as therapy for radiation necrosis in four children with pontine gliomas.Int J Radiat Oncol Biol Phys. 2009 Nov 15;75(4):1148-54

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