We’ll be taking a break from blogging over the festive period, but we’ll be back in January with more top science, myth-busting and podcasts. In the meantime, here’s a quick run-down of some of the biggest stories that we’ve covered on the blog this year.
And the following month, the spotlight shone on our Gray Institute for Radiation Oncology and Biology in Oxford – where researchers announced that cancer cells appear to spread along blood vessels in the brain, rather than nerve cells as previously thought. Their finding changes the way we think about how cancer spreads to the brain, and how we might develop treatments to prevent it.
In August our media spokespeople were kept busy commenting on an important breakthrough from scientists in the US, who might have found a way to target the faulty stem cells that are thought to lie at the heart of a number of cancers.
And despite December’s chill, our hearts were warmed last week by the announcement that scientists at the Wellcome Trust Sanger Institute had mapped the entire genomes of cancer cells from a melanoma and a lung cancer patient, as well as corresponding healthy cells. Their groundbreaking work reveals detailed molecular insights into the development of cancer, and sets the scene for rapid progress in understanding how cancer develops – and hopefully how to treat it more effectively.
That’s just a brief round-up of some of the exciting progress that’s been made over the last twelve months – much of it a result of the hard work of our scientists, and supported by your generous donations. Thank you so much.
And on that note of gratitude, we wish you a very merry Christmas and a happy new year – see you in 2010!
Siim Pauklin, Isora V. Sernández, Gudrun Bachmann, Almudena R. Ramiro, Svend K. Petersen-Mahrt (2009). Estrogen directly activates AID transcription and function The Journal of Experimental Medicine
Chisholm, E et al (2009). Cancer-Specific Transgene Expression Mediated by Systemic Injection of Nanoparticles Cancer Research, 69 (6), 2655-2662 DOI: 10.1158/0008-5472.CAN-08-2657
Lubbe, S. et al (2009). Implications of Familial Colorectal Cancer Risk Profiles and Microsatellite Instability Status Journal of Clinical Oncology DOI: 10.1200/JCO.2008.20.3364
Attard, G. et al (2009). Selective Inhibition of CYP17 With Abiraterone Acetate Is Highly Active in the Treatment of Castration-Resistant Prostate Cancer Journal of Clinical Oncology DOI: 10.1200/JCO.2008.20.0642
Cawood, R., Chen, H., Carroll, F., Bazan-Peregrino, M., van Rooijen, N., & Seymour, L. (2009). Use of Tissue-Specific MicroRNA to Control Pathology of Wild-Type Adenovirus without Attenuation of Its Ability to Kill Cancer Cells PLoS Pathogens, 5 (5) DOI: 10.1371/journal.ppat.1000440