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Zometa: suspect in kidney function changes

Posted Jan 05 2010 12:00am

Now that we are all back to work I was able to talk with my hemonc nurse, so we have a plan. Per a few readings on my urine and blood tests (including a rising creatinine level) it appears that something is affecting my kidney function. It seems the wonderful Zometa®, which helps the body to rebuild bone, can become renal toxic. This is, of course, an unwelcome side effect, so we’ll look at options starting with more blood tests and then a decision about how to deal with the problem.

Renal function is important, of course, for vacating waste, but it’s also important because healthy kidneys produce erythropoietin (EPO), the hormone that regulates the bone marrow’s production of red blood cells. Impaired kidney function produces less erythropoietin, which causes or exacerbates anemia. I have had anemia since my diagnosis and treatment of the bone mets, so my oncologist seems to be sensitive to anything that can increase that condition.

So now I am reading and researching information so I can understand what’s going on and what I can do, if anything, to help.

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