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ferroportin level may predict breast cancer prognosis

Posted Aug 09 2010 12:00am

Scientists may have identified a predictor of a woman’s prognosis for recurrence of breast cancer. Ferroportin is a protein that regulates iron’s metabolism and activity, or in this context, its utilization by cancer. Cancer cells grow with the presence of iron, and scientists believe it may grow more aggressively, as well, with iron. When low levels of ferroportin were present, it appears that cancer cells were more aggressive. When normal levels of ferroportin were present, cancer cell activity appeared to be reduced.

Note that the iron here is not dietary but cellular iron, which is only produced by the body rather than ingested.

Zandra K. Pinnix, Lance D. Miller, Wei Wang, Ralph D’Agostino Jr., Tim Kute, Mark C. Willingham, Heather Hatcher, Lia Tesfay, Guangchao Sui, Xiumin Di, Suzy V. Torti and Frank M. Torti. Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis. Sci Transl Med 4 August 2010: Vol. 2, Issue 43, p. 43-56

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© 2004-2010 Donna Peach. All rights reserved.

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