Curcumin Analog Has Breast Cancer Fighting Properties
Posted Aug 11 2010 7:31am
Curcumin is the main component of turmeric, a spice derived from Curcuma longa, a member of the ginger family. Some of my previous blogs have discussed the potential breast cancer fighting benefits of natural curcumin as well as a couple of curcumin-derived compounds. The results of these studies to date have been very positive, showing curcumin's cancer fighting properties.
A new breast cancer research study published in Breast Cancer Research and Treatment continues to extol the breast cancer fighting benefits of curcumin-based compounds . Using a number of different cell culture studies and animal studies, these breast cancer researchers tested the ability of curcumin and two curcumin analogs, called PAC and EAC, to suppress breast cancer. The results of this new breast cancer research showed that
PAC was five times more effective at causing programmed cell death of breast cancer cells than EAC and natural curcumin.
The ability of PAC to cause cell death as 10-fold greater in estrogen receptor negative (ER-) breast cancer cells than in estrogen receptor positive (ER+) breast cancer cells.
PAC inhibited the progression of the breast cancer cells' normal growth cycle with this inhibition being greater in ER- cells than ER+ breast cancer cells.
Treatment with PAC altered several cellular compounds involved in cell growth and immune function in directions favorable for cancer protection.
Giving PAC to mice with implanted breast cancer tumors caused a reduction in breast cancer tumor size.
These are exciting breast cancer research results that further show the potential of curcumin and curcumin-derived compounds for breast cancer protection. While previous research has shown that natural curcumin has cancer fighting benefits, particularly for triple negative breast cancer, recent research studies, including this current study, suggest that curcumin-derived compounds might be even more effective. According to this current breast cancer study, not only was PAC substantially more effective than natural curcumin, but it was also more widely distributed and available in the bodies of the mice tested. Despite all of the positive research about curcumin being published lately, additional studies in human volunteers will need to be conducted to determine the effectiveness and safety of these new curcumin analogs. While we wait for these studies to be done, curcumin can be easily added to the diet as part of our personal fight against breast cancer.