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The Early Descriptions of Ammon's Horn Sclerosis

Posted Aug 24 2008 11:31pm
A reader requested a post about epilepsy. In searching the internet, I found a nice article by Keiji Sano from Teikyo University School of Medicine in Japan which describes the history of hippocampal epilepsy surgery for Ammon’s horn sclerosis (AHS). Here’s an excerpt from Sano’s article. I should note that when Sano refers to the “endplate” or “end folium”, he is referring to the CA4 region of the hippocampus, which I have now learned can also be referred to as Bratz’s sector:

“The first gross description of AHS is generally credited

to Bouchet and Cazauvieilh, who in 1825 observed

changes of sclerosis or softening in the hippocampus

of epileptic as well as of nonepileptic psychopathic

patients. Sommer performed the first microscopic examination

of AHS in 1880, showing the changes to be

restricted to the band of pyramidal cells of the hippocampus,

which has since been called “Sommer’s sector.”

He also coined the term “Amrnonshornsklerose.”

In 1889, Chaslin described a marginal gliosis in cases

of epilepsy and regarded AHS sclerosis as representing

merely a site of predilection for such gliosis. In 1899,

Bratz confirmed Sommer’s findings but noted that

the endplate or the end folium was as often affected as

Sommer’s sector (and therefore later called Bratz’s sector)

and that a portion of the dorsal cell band was resistant

in many cases. He determined that AHS existed in

25 of 50 cases of idiopathic epilepsy and also noted the

same lesion in other diseases associated with convulsive


Epilepsia, 38(Suppl. 6):4-10, 1997

Lippincott-Raven Publishers, Philadelphia

0 International League Against Epilepsy

Here’s a link to the full article:'submitPDF=Full+Text+PDF+%28828+K
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