Many of us who have had Deep Brain Stimulation (DBS) surgery experience some "adverse effects" (or "trials and tribulations" as my friend, Valerie describes them).
Adverse Events after DBS Surgery
From Viartis
New Research – March 30, 2008
Movement Disorders [2008] 23: 343-349 (A Videnovic, L Verhagen Metman)
DBS is a surgical method of treating Parkinson's Disease that uses electrodes implanted into the brain. Traditionally, the two most common sites in the brain used in surgery are the subthalamic nucleus (STN) and the globus pallidus interna (GPi). The authors analysed reports of adverse events from over a thousand patients who had undergone DBS surgery. The most common adverse events were, in order: weight gain, then confusion, then speech difficulties. Neither part of the brain that was used had clearly fewer adverse events than the other. Adverse events related to DBS surgery are common, but the study authors concluded that their true prevalence cannot be accurately determined with current reporting methods.
See complete article at: http://www.mdvu.org/emove/article.asp?ID=1029
The most common adverse events were:
Procedure related events (% of STN/% of GPi):
Mental status/behavior (mostly confusion) 18%/9%
Infection 2%/3%
ICH-symptomatic 2%/4%
Misplaced electrode 2%/2%
Speech disturbance 2%/4%,
Infarction 1%/2%.
Stimulation or progression related events (% of STN/% of GPi):
Weight gain 37%/18%,
Dysarthria (speech disorder) 13%/12%
Eye opening apraxia 11%/0%
Gait ignition failure 0%/17%.
Hardware-related events (Combined % of STN and GPi):
One or more events 9%
Infection 2%
Malfunctioning 1%
Lack of benefit 1%.
Full Abstract:
Deep brain stimulation for Parkinson's disease: prevalence of adverse events and need for standardized reporting.
Videnovic A, Metman LV.
Section of Movement Disorders, Rush University Medical Center, Chicago, Illinois 60612, USA. aleksandar_videnovic@rush.edu
Deep brain stimulation (DBS) has assumed a prominent role in the treatment of Parkinson's disease (PD). In this manuscript, we attempt to estimate the prevalence and categorize adverse events (AEs) of DBS in PD, based on efficacy studies published over the last decade. We conclude that reliable categorization and quantification of AEs based on available data poses many challenges and argue that a standardized scheme for reporting AEs should be created. This would provide a foundation for a meaningful risk/benefit analysis, for comparison of results between centers and, ultimately, for a well informed decision by physicians and patients as to whether surgery should be pursued. 2007 Movement Disorder Society
PMID: 17987644 [PubMed - in process]
Adverse Events after DBS Surgery
From Viartis
New Research – March 30, 2008
Movement Disorders [2008] 23: 343-349 (A Videnovic, L Verhagen Metman)
DBS is a surgical method of treating Parkinson's Disease that uses electrodes implanted into the brain. Traditionally, the two most common sites in the brain used in surgery are the subthalamic nucleus (STN) and the globus pallidus interna (GPi). The authors analysed reports of adverse events from over a thousand patients who had undergone DBS surgery. The most common adverse events were, in order: weight gain, then confusion, then speech difficulties. Neither part of the brain that was used had clearly fewer adverse events than the other. Adverse events related to DBS surgery are common, but the study authors concluded that their true prevalence cannot be accurately determined with current reporting methods.
See complete article at: http://www.mdvu.org/emove/article.asp?ID=1029
The most common adverse events were:
Procedure related events (% of STN/% of GPi):
Mental status/behavior (mostly confusion) 18%/9%
Infection 2%/3%
ICH-symptomatic 2%/4%
Misplaced electrode 2%/2%
Speech disturbance 2%/4%,
Infarction 1%/2%.
Stimulation or progression related events (% of STN/% of GPi):
Weight gain 37%/18%,
Dysarthria (speech disorder) 13%/12%
Eye opening apraxia 11%/0%
Gait ignition failure 0%/17%.
Hardware-related events (Combined % of STN and GPi):
One or more events 9%
Infection 2%
Malfunctioning 1%
Lack of benefit 1%.
Full Abstract:
Deep brain stimulation for Parkinson's disease: prevalence of adverse events and need for standardized reporting.
Videnovic A, Metman LV.
Section of Movement Disorders, Rush University Medical Center, Chicago, Illinois 60612, USA. aleksandar_videnovic@rush.edu
Deep brain stimulation (DBS) has assumed a prominent role in the treatment of Parkinson's disease (PD). In this manuscript, we attempt to estimate the prevalence and categorize adverse events (AEs) of DBS in PD, based on efficacy studies published over the last decade. We conclude that reliable categorization and quantification of AEs based on available data poses many challenges and argue that a standardized scheme for reporting AEs should be created. This would provide a foundation for a meaningful risk/benefit analysis, for comparison of results between centers and, ultimately, for a well informed decision by physicians and patients as to whether surgery should be pursued. 2007 Movement Disorder Society
PMID: 17987644 [PubMed - in process]