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A 32-year-old HIV+ male presenting with mental status changes

Posted Oct 01 2012 5:25pm
 Soon after admission, the patient lapsed into a coma and died.

Minimal edema (brain weight: 1500 grams)

Some hypoxic-ischemic damage as evidenced by Purkinje red neuron change
"Soap bubble" changes around some vessels (sample from basal ganglia)
Giant cells among mixed inflammatory infiltrate in the meninges
Inflammation appears to extend minimally into brain parenchyma
Organisms consistent with crytopcoccus neoformans amid inflammation
Mucicarmine-positive fungi capsules highlighted in red, with some capsules partially deficient
Diagnosis: Cryptococcal meningoencephalitis with early hypoxic-ischemic encephalopathy.
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