Emotions, stressors, and HPA axis function in bipolar disorder
Posted Dec 20 2009 7:50pm
Psychoneuroendocrinology: Emotions, stressors, and hypothalamic-pituitary-adrenal (HPA) axis function in bipolar disorder
Multiple lines of evidence suggest the intense emotional responses elicited by environmental stressors negatively influence the relapse rate of bipolar disorder episodes. Research results have consistently shown heightened physiological and psychological reactivity in bipolar disorder following stress cues in manic, depressed, and euthymic states. This enduring hyperactive HPA axis and resulting hypercortisolemia is suspected to be the antecedent to the lowered N-acetylaspartate concentrations observed in the hippocampi of bipolar subjects. The efficacy of antiglucocorticoids (as used to reduce high cortisol levels in Cushing’s syndrome) to treat hypercortisolemia and dysfunctional HPA axis is in the beginning stages of exploration. Further investigation into the neurobiology of mood disorders and hypercortisolemic symptomatology in medical conditions is warranted. Review of current literature and directions for future research are discussed.
My research review paper is almost done. The above is a draft of the abstract for it. I don't know how to upload PDF files to blogger, so I am not able to provide an actual electronic copy to those who are intersted. If you email me, using the "Contact" form at the top menu selections, I am more than happy to send the file your way :)
Back to obsessing about research and what-not. I am obsessing. Hard core. And I am tired. And my head hurts. :) but it's all good because I have my brain and it is generally smart and will take me to graduate school :)