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Measles Vaccine Prevents Autism?

Posted Feb 17 2010 4:30pm

I blogged this in the past when the paper went online, but it is now “in print”:

Lack of Association Between Measles-Mumps-Rubella Vaccination and Autism in Children: A Case-Control Study
Mrozek-Budzyn D, Kietyka A, Majewska R.

From the Department of Epidemiology and Preventive Medicine, Jagiellonian University, Collegium Medicum, Krakow, Poland

Study shows lower autism rate in vaccinated kids than in those who didn’t get the measles or the MMR vaccine. The timing of the publication is funny. I am surprised that there hasn’t been a call of “conspiracy” that this was released so close to all the recent drama.

Here is the abstract:

OBJECTIVE:: The first objective of the study was to determine whether there is a relationship between the measles-mumps-rubella (MMR) vaccination and autism in children. The second objective was to examine whether the risk of autism differs between use of MMR and the single measles vaccine. DESIGN:: Case-control study. STUDY POPULATION:: The 96 cases with childhood or atypical autism, aged 2 to 15, were included into the study group. Controls consisted of 192 children individually matched to cases by year of birth, sex, and general practitioners. METHODS:: Data on autism diagnosis and vaccination history were from physicians. Data on the other probable autism risk factors were collected from mothers. Logistic conditional regression was used to assess the risk of autism resulting from vaccination. Assessment was made for children vaccinated (1) Before diagnosis of autism, and (2) Before first symptoms of autism onset. Odds ratios were adjusted to mother’s age, medication during pregnancy, gestation time, perinatal injury and Apgar score. RESULTS:: For children vaccinated before diagnosis, autism risk was lower in children vaccinated with MMR than in the nonvaccinated (OR: 0.17, 95% CI: 0.06-0.52) as well as to vaccinated with single measles vaccine (OR: 0.44, 95% CI: 0.22-0.91). The risk for vaccinated versus nonvaccinated (independent of vaccine type) was 0.28 (95% CI: 0.10-0.76). The risk connected with being vaccinated before onset of first symptoms was significantly lower only for MMR versus single vaccine (OR: 0.47, 95% CI: 0.22-0.99). CONCLUSIONS:: The study provides evidence against the association of autism with either MMR or a single measles vaccine.

It is not the strongest study. But it adds yet more information to the conclusion: the MMR causation theory is basically dead.

This paper has also been blogged by Steven Novella and Orac.

More recently, Laurentius Rex has blogged it. I thank him for commenting here and reminding me about the study and, mostly for this line from his blog:

It is not my usual procedures to copy articles but this one certainly kicks the monkey study in the balls.

If you want to reference this post in your site, use the code below to link to me from your website.

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