Looking for Mitochondrial Disorders In Your Autistic Child
Posted Jun 16 2008 6:11pm
So there has been much, "How do i know if my child has a mitochondrial disorder" discussion these days. Here is a blurb from David Kirby on the biomarkers to look for that could point toward mito dysfunction. Discuss them with your doctor.
"1) Mark Blaxill sent this to me. It is a sample list of some of the higher estimates of mitochondrial imbalances in autism samples. Most of these are elevated relative to a reference range.
1. 47% (elevated serum creatine kinase, Poling et al)
2. 38% (elevated plasma aspartate aminotransferase, Poling et al) vs. 22% in controls
3. 28% (elevated plasma lactate/pyruvate ratio, Correia et al)
4. 20% (elevated plasma lactate, Oliveiro et al)
5. 17% (elevate plasma lactate, Correia et al)
6. 13-16% (two hyperlactidemia markers, Oliveiro et al)
7. 65% - Shoffner (I need to check this abstract – DK)
2) Another ASD doctor, who does not specialize in mito disorders, went back and looked at blood work from his patient caseload in Jan 08. A high lactate/low pyruvate ratio is one marker (though a child who squirms during a blood draw can have elevated levels, though Poling and others try to control for false negatives)
This is what the pediatrician found:
168 total visits (consecutive) 147 different patients (consecutive) 67 had blood lactate done in clinic and sent stat to the local hospital (45.5% of patients) 21/67 had a blood lactate above the normal reference range (31.3%)