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Japanese Data Show Vaccines Cause Autism

Posted Jul 02 2009 9:39pm

Posted on June 3, 2009 by childhealthsafety

Just months following the US Court of Federal Claims rejection of the claim that the MMR vaccine causes autism, hereyou will see data from formal peer refereed medical papers showing that vaccines caused autism in Japanese children and will be doing the same to children around the world. The number of Japanese children developing autism rose and fell in direct proportion to the number of children vaccinated each year [click image for larger graph in new window]:-

080603_terada_graph
[See end of page for alternative version of this graph normalised by annual % of children receiving MMR vaccination - but also showing the same correspondence as above graph.]


Contents

Introduction & Peer Review

Flawed “Science” By Doctors Not Scientists

The Invalid Claims of Honda and Rutter

The Vaccination Data Honda/Rutter Omitted

Japanese Autism Numbers Rose & Fell With Vaccinations

The Power of Rechallenge

Professor Sir Michael Rutter & The Drug Industry Connections

What You Can Do

To Contents

Introduction & Peer Review

The “science” from medical journals presented to courtsis not reliable.The medical “science” evidence-base has become institutionally and systemically corrupt sinceRonald Reagan introduced the Bayh-Dole Act in the 1980’s : [" Doctors Without Borders - Why you can't trust medical journals anymore" by Shannon Brownlee, Washington Monthly].

Mainstream medical journals live off drug company advertising. Government health officials, drug company lobbyists and medical professionals tell us: it is “science” and “proof” when it is not.

Covert lobbying is endemic:-

‘The use of PR to counter negative publicity’

‘221. ………. Considerable resources are invested into building long-term, sustainable relationships with stakeholders and ‘ key opinion leaders ‘ and journalists. These relationships are used to promote the use of certain brands and counter concerns relating to safety. Efforts to undermine critical voices in particular were identified, under terms of “issues management”. In later evidence, in response to the ISM’s memorandum, Pfizer stated that PR is entirely legitimate and can “help to educate and inform”. According to the PMCPA, PR activities may include “ placing articles in the lay press, TV documentaries, soap operas etc “.’ [p60 'The Influence of the Pharmaceutical industry' 2004- English Parliamentary Health Select Committee report [emphasis added]]


Peer Review of Data

The data and analysis shown here has been through a process of peer review.Publication is responsible to bring it to public attention.

The peer review process included presenting this information to:-

  • Hideo Honda correspondent author of the main paper. Result – no comment, rebuttal or answer [correspondence twice sent to address for correspondence on the paper];
  • Professor Tony Charman, Editor of the publishing journal. Result:- refusal to comment, rebut, answer or publish a correction or retraction [although correspondence sent was received];
  • UK’s Joint Committee on Vaccination and Immunisation, Chairman Professor Andy Hall. Result: no comment, rebuttal or answer [although correspondence sent was received];
  • Head of UK Health Protection Agency. Result: no comment rebuttal or answer [although correspondence sent was received];
  • the publishers Blackwell Publishing. Result: no comment, rebuttal or answer[although correspondence sent was received].

It has also been presented to others including an expert in the assessment of adverse drug reactions who confirmed data showing such a close correspondence is remarkable in post marketing surveillance and rarely if ever seen – probably unique.

Flawed “Science” By Doctors Not Scientists

In 2005 a paper by two Japanese psychiatrists, Hideo Honda and Yasuo Shimizu, was published in an English psychiatric journal with English psychiatrist Professor Sir Michael Rutter also named as an author. The paper was claimed to be proof MMR vaccine could not cause autistic spectrum disorders: [“ No effect of MMR withdrawal on the incidence of autism: a total population study.” Journal of Child Psychology and Psychiatry (2005)].

These three psychiatrists failed to provide the full picture. They made invalid claims [See more belowThe Invalid Claims]. Those claims were based on inadequate research containing basic flaws.Psychiatrists are not usually also trained scientists and normally lack scientific qualifications.When the flaws in their paper are identified and corrected, the paper provides unusually strong evidence, not normally seen, showing vaccines as a cause of Autistic Spectrum Disorders (ASD).

The paper shows, when corrected with the missing data, Autistic Spectrum Disorder numbers increased and decreased in direct proportion to the total number of children vaccinated.We see here not just evidence of dechallenges and rechallenges but a “dose-response” relationship on a population level.

A dose-response relationship on a population level is rare if not unprecedented. The close numerical correspondence seen here is usually not found. This is conclusive evidence of a causal association.

The Honda/Rutter paper claimed that new cases of autism in Japan fell for children born in 1991-92 (as the confidence of Japanese parents fell in the dangerous Japanese MMR vaccine withdrawn on safety grounds in 1992) but then rose sharply again and especially for children who were born in 1993-94. Here is the graph from the Honda/Rutter paper:-

[ larger graph in new window ]

honda2

The authors summarised their results (emphasis added):-

The MMR vaccination rate in the city of Yokohama declined significantly in the birth cohorts of years 1988 through 1992, and not a single vaccination was administered in 1993 or thereafter. In contrast, cumulative incidence of ASD up to age seven increased significantly in the birth cohorts of years 1988 through 1996 andmost notably rose dramatically beginning with the birth cohort of 1993.

The authors wrongly claimed this meant it was unlikely MMR vaccine caused autism spectrum disorders. They made this claim without any “control” – a scientific fundamental – something to compare against MMR – a scientific benchmark or yardstick to see if there was any difference compared with something else.

As can be seen from the above Honda/Rutter graph, in 93-94 and after, the autism rate was double that in the period up to 1992 [when the MMR vaccine was withdrawn]. The authors were duty bound to consider this before going into print. Their data put them on notice that withdrawing the proven dangerous Japanese MMR vaccine was associated with a marked drop in new cases of autism. That is clear from their graphs. Autism cases fell for those born in 1991-92 as uptake of the Japanese MMR vaccine fell and was withdrawn in 1992.

The authors failed to do what any scientist would have done. They failed to ask themselves why?.Why did autism rapidly increase for children born in 1993-94 and thereafter?

And there was something to compare against the MMR. Honda/Rutter did not use it.

The MMR was replaced with single measles and single rubella vaccines. These were given at or about at the same time. And also at the same time the overall vaccination rate in Japan was increased by 150%.

When this happened the autism rate increased in step.

The only thing Honda/Rutter teaches us is that MMR cannot be the only cause – and not that it is not a cause of autism.

Professor Rutter has close associations with the drug industry including GlaxoSmithKline. He was a paid expert witness on their behalf in the UK MMR vaccine damage litigation. That was not declared in the Honda/Rutter paper nor were any other potential conflicts of interest or statements of funding (about which see more below ).

Professor Rutter is also one of the main prosecution witnesses in the witchhunt in the British General Medical Council against medical doctors Andrew Wakefield, Simon Murch and Professor Walker-Smith.

The Invalid Claims

The Honda/Rutter paper when corrected provides not only strong evidence that MMR and single measles vaccines are causes of ASD but it also implicates as causes of ASD the rubella vaccine and JE (Japanese Encephalitis) vaccine containing Thiomersal [Thimerosal in the USA]. Thiomersal is a known toxic mercury containing neurotoxin and also causes allergies.It is toxic in parts per billion.

Japanese Encephalitis vaccine was given in three separate vaccinations and each one contained the poisonous mercury based neurotoxin thiomersal. So JE vaccine is just like DTP given to children in the USA and UK up until very recently in that it contained that neurotoxin and was given in three jabs to infants or toddlers.

That the practice in Japan was to give the measles and rubella vaccines at the same time was the boast of The British Department of Health. That was to bolster official claims that whistle blower medical doctor Andrew Wakefield’s concerns about the MMR vaccine were wrong. The Honda/Rutter paper was announced in the usual blaze of publicity. And as usual, the truth has not been. No one can argue validly that scientifically the Honda/Rutter paper is not deeply flawed.

In Japan when MMR was introduced, single measles vaccine was still being used side-by-side with MMR. Professor Rutter and his colleagues failed to take that into account.They also failed to look to two peer refereed papers published only three years earlier in 2002 which provide some of the missing data:-

The Nakatani and Terada papers provide a more complete picture. The Terada paper sets out the annual Japanese vaccination data for the annual numbers of vaccinations for measles and MMR vaccines combined in Kurashiki City, Japan. The Nakatani paper sets out the overall national Japanese vaccination data for all regions including Yokohama. Its data includes vaccine uptake in Japan for measles, rubella and the mercury containing Japanese Encephalitis vaccine.

In addition Honda/Rutter missed another Japanese paper from 2003 – Takahashi – claiming the r isk of autism could be between 5 and 9 times greater from single measles and rubella vaccines, so Honda/Rutter have no excuses for not considering this possibility and including the single vaccines as a control or comparison group:

Jpn. J. Infect. Dis., 56, 114-117, 2003

The Takahashi paper is further direct evidence of a link between vaccines and autism – despite repeated denials by health officials, “expert” panels, medical professionals and journalists that there is no evidence of such a causal link.

Grateful thanks for generously making his library facilities available pro bono publico without condition or hesitation, and especially so for enabling the key Terada paper to be located are due to Professor Jeff Bradstreet MD, MD(H) FAAFP, Adjunct Professor of Pediatrics, Southwest College of Naturopathic Medicine, International Child Development Research Centre, Melbourne, FL 32934, USA. It is certain some children and their families could be saved from a lifetime of autism if the information here becomes more widely available to parents, independently minded physicians and other medical practitioners.

Japanese Autism Numbers Rose & Fell With Vaccinations

When Honda/Rutter is compared to Terada it can be seen that ASD numbers rose and fell in direct proportion to the total number of children vaccinated in any year. In other words, the number of Japanese children who developed autism was directly related to the number who received MMR, single measles, rubella and Japanese Encephalitis vaccines. Here is a combined graph showing this:-

[ larger graph in new window ]

080603_terada_graph

This is a dose-response relationship – the extent of the effect of a drug is related to the amount of the drug administered. Unusually, we see a dose-response relationship on a “population level” in a large sample of the child population of Japan, and as such, this is conclusive evidence of a causal association between vaccination and Autistic Spectrum Disorders in children.

Immediately below is the data from the Terada and Honda/Rutter papers shown separately in the graphs, from the original papers as published:-

[ larger Terada graph in new window ]

[ larger Honda/Rutter graph in new window ]

Terada Paper: Fig. 4 Numbers of measles vaccinations and births in Kurashiki City from 1980 to 2000
teradagraph
Red Line joins tops of bars. It shows the total of MMR and Measles vaccinations each year in Kurashiki City from 1980 to 2000.
Honda/Rutter Fig. 1: Numbers of ASD diagnoses in children up to 7 years of age by year of birth
honda2

These graphs compare data for children born in two different areas: Kurashiki City with Kohoku Ward, Yokohama. The correspondence is remarkable. [ Note when comparing the first graph, Japanese children were vaccinated when 15-18 months old - so the comparison of ASD rates by year of birth is with the vaccination rates approximately two years later. The first graph is 15-18 months “ahead” of the second.]

Further, the Nakatani paper indicates this similarity in the data is unlikely to be coincidence: [ Development of Vaccination Policy in Japan: Current Issues and Policy Directions, Hiroki Nakatani,Tadashi Sanoand Tsutomu Iuchi Jpn J Infect Dis 55 101-111 2002]. The Nakatani paper shows the national vaccination rates in Japan. These are closely similar in profile to that shown for Kurashiki City. It is also reasonable to expect that the national vaccination rates would be similar for Kohoku Ward (data in the Honda/Rutter paper).

It is the Nakatani paper which implicates rubella vaccine and the thiomersal/thimerosal mercury containing JE (Japanese Encephalitis) vaccines along with MMR and Japanese Encephalitis vaccine. The Nakatani paper shows that in 1995 there was a sharp rise (150%) in single measles and single rubella vaccinations. Many of the children getting those vaccines in 1995 would have been those born in 1993-4. This rise was also coupled with a doubling in Japanese Encephalitis vaccinations (200%) between 1993 and 1995.

Here is the graph from the Nakatanipaper showing the increases in single measles, rubella and JE vaccine vaccination rates by 1995 in Japan – the vertical blue line has been added to highlight the year and the legend ringed in blue to pick out the measles, rubella and JE vaccine lines of the graph:-

[ larger Nakatani graph in new window ]

japvaccrise

And after the 150% increase in measles and rubella vaccinations and the doubling in the JE vaccine uptake, the graph shows that autism incidence doubled.

Incidence rose from 60 in 10,000 (1991-92 births) to 120 in 10,000 (1995-96 births). The same applies to the peaks in the graph in 1990 and 1994. The 1990 peak was 80 in 10,000 and the 1994 peak was double that at 160 in 10,000.

Grateful thanks to to Dr F E Yazbak of Boston Massachusetts, USA for drawing attention to the Nakatani paper and so assisting to identify this population level rechallenge proof of autism causation of the MMR and mercury containing vaccines.

This shows that not only did the authors of the Honda/Rutter paper have before them evidence of a “population level” dechallenge, they also had evidence of a “population level” rechallenge. Had they carried out their researches properly, they would also have had the evidence of the Nakatani and Terada papers to show the powerful evidence of a dose-response relationship on a population level.

How Comparable Are These Two Cities?

The graph below demonstrates how comparableKurashiki City and Yokohama are forMMR vaccination uptake. This isin addition to the national figures for Japan from the Nakatani paper which apply to both cities. The Nakatani figures show[for the second autism peak in the Honda/Rutter paper for children born in 1994] there was 150% increase in single vaccine uptake throughout Japan and a 200% increase forThiomersal containing Japanese Encephalitis vaccine. [These increases followed the change in the national Japanese vaccination law in 1994. Children born that year would have been vaccinated 15-18 months later with MMR and 12-24 months later with JE vaccine].

[Click graph for larger version in new window].

090610 Kurashiki vs Yokohama MMR Uptake

Just one well documented spontaneous report of a rechallenge is sufficient to prove a drug causes a harmful adverse drug reaction. Only three well documented cases of dechallenge are sufficient proof.

But here we see these numerous dechallenges and rechallenges combining into a continuous dose-response relationship on a population level. This is unusual and powerful proof of a causal association.

“Dechallenge” is the withdrawal of the administration of a drug from a person after they have been taking it. If adverse symptoms suffered by the person diminish with withdrawal of the drug, that is evidence the reaction is caused by the drug. “Rechallenge” is where the same drug is reintroduced and the adverse reactions start again. This is standard well-known and well-accepted pharmacological science.“Spontaneous” means you do not have to carry out a drug trial. If it happens to an ordinary patient at any time anywhere but is well documented, that can be sufficient proof.

Here, we see the Honda/Rutter paper in conjunction with the Nakatani paper providing us with a large number of examples of dechallenges and rechallenges. This is not in a few individuals but in large samples of the child population of Japan. And the dechallenges and rechallenges are well documented in published peer refereed papers.

The Terada paper also shows us that in this sample Japanese population (hence the term “population level”) the dechallenges and rechallenges combine to show us a population level dose-response relationship. That means we see the adverse effects increasing and decreasing in proportion to the quantity of the pharmaceutical (here vaccines) administered to the sample population. That is powerful as proof of a causal association between the vaccines and autistic spectrum disorders.You can read further about the power of dechallenge and rechallenge evidence in this peer refereed medico-legal paper by Professor Donald Miller MD, professor of surgery at the University of Washington and published in the Journal of American Physicians and Surgeons:-

On Evidence, Medical and Legal

The Honda/Rutter graph shows that autism incidence was rising over the entire period from 1988 to 1996. Thus this is more evidence to confirm the world autism pandemic, and which is other evidence the Honda/Rutter authors had before them which they did not deal with.

Professor Sir Michael Rutter & The Drug Industry Connections

It is appropriate to ask:

  • who is Professor Sir Michael Rutter?
  • might he at least subconsciously suffer from author bias?
  • does he have any potentially conflicting interests?”

It can help to follow the money. In the money connections, you don’t get any bigger than Rutter.Psychiatrist Professor Sir Michael Rutter is a former (recent) Deputy Chairman of the immensely wealthy Wellcome Trust (founded by the Wellcome Foundation which is now Glaxo). For confirmation of his status, see the 4th page of :-

The Wellcome Trust has assets of over £14 billion:-

The Trust hands out millions every year and has far more substantial reserves to enable it to do that. And it can dictate a great deal of what research is carried out around the world. See here for details:-

So Rutter is very influential. You do not get to be in that position if you are not “in favour with pharma”.He is also one of the expert witnesses for Glaxo in the MMR litigation (something he did not declare, for example, in the Honda/Rutter paper denying MMR has any association with autism, but I do not see him before the GMC over that). Professor Rutter is also one of the main prosecution witnesses in the witchhunt in the British General Medical Council against medical doctors Andrew Wakefield, Simon Murch and Professor Walker-Smith.Here is a biographical note on Professor Sir Michael Rutter from the Academy of Medical Sciences which says:-

Professor Sir Michael Rutter is Professor of Developmental Psychopathology at the Institute of Psychiatry, Kings College, London. He has been a consultant psychiatrist at the Maudsley Hospital since 1966, and was Professor of Child Psychiatry at the Institute of Psychiatry from 1973 to 1998. He set up the Medical Research Council Child Psychiatry Research Unit in 1984 and the Social, Genetic and Developmental Psychiatry Centre 10 years later, being honorary director of both until October 1998. His research has included the genetics of autism; the study of both school and family influences on children’s behaviour; the links between mental disorders in childhood and adult life; epidemiological approaches to test causal hypotheses; and gene-environment interplay. He was Deputy Chairman of the Wellcome Trust from 1999 to 2004, and has been a Trustee of the Nuffield Foundation since 1992. He was elected a Fellow of the Royal Society in 1987 and an honorary member of the British Academy in 2002. He was a Founding Fellow of the Academia Europaea and the Academy of Medical Sciences, of which he is currently Clinical Vice-President. He has received numerous international honours and has published some 40 books and over 400 scientific papers and chapters.

Professor Sir Michael Rutter along with a troupe of psychiatrists now or formerly associated with The Maudsley Hospital and The Institute of Psychiatry at Kings College, London University, have been working hard at telling the public autism is solely genetic and denying there is a world autism pandemic.If a condition is genetic, you also do not suddenly get spontaneous mutation of large numbers of individuals. That suggestion is counter logical and non science. Genetics cannot account for the large rise we are seeing in autism since the mid 1980s. So instead what we see are efforts by Rutter and the King’s Institute of Psychiatry other autism denialists to claim there is no real rise in the prevalence of autism. This claim is unscientific and runs counter to the facts documented in the formal literature.

The Institute of Psychiatry has been an embarrassing place to be because of this April 2008 news item:-

BBC psychiatrist Tonmoy Sharma is struck off By Lucy Cockcroft The Telegraph 01 April /2008A psychiatrist who regularly appeared as an expert on the BBC has been struck off the medical register after he lied about his academic qualifications and performed unethical drugs tests on mentally ill patients.

The Institute of Psychiatry has or is home to more than its fair share of doctors (psychiatrists mostly) who publish papers claiming autism is genetic and denying there is an autism epidemic (the correct word is pandemic – epidemics have far fewer victims). These doctors include Rutter, Eric Fombonne (now expert witness in the US in the thiomersal/autism litigation when he had previously published nothing about it) and Professor Simon Baron Cohen.

It is also home to controversial “Gulf War Syndrome” psychiatrist Simon Wessley, director of the Centre for Military Health Research at King’s College London and who had been claiming ME/CFS is not a physical condition but a mental one contrary to the definition used around the world. Sophia Wilson is an example of an ME/CFS sufferer who died following this approach to diagnosis, albeit there is no evidence available to this author she was ever a patient of any of the psychiatrists or institutions name here.

Also associated with The Institute of Psychiatry and the Maudsley is Dr Ben Goldacre, who constantly attacks alternative medicine in The Guardian [a UK national newspaper] whilst writing the “Badscience” column – yet Goldacre has no scientific qualifications and avoids disclosing that he practises psychiatry. Psychiatry is the least successful branch of medicine in history and is notorious for a lack of scientific bases to support the theories some of its proponents put out.Goldacre works with Wessley.

Goldacre and Wessley have close professional and personal connections to King’s Mobile Phones Research Unit. Goldacre has made public attacks, backed by the industry funded lobby group, The Science Media Centre, on a BBC Panorama documentary about mobile phone hazards, which hazards were raised by the current head of the UK’s Health Protection Agency, before taking up that post. Ben Goldacre and The Science Media Centre attacked the programme and its journalists.

Professor Rutter is also a friend of the editor of the journal which printed the Honda/Rutter MMR paper. Here is his endorsement of the Journal:-

JCPP is clearly the world’s No. 1 child psychology and psychiatry journal. It integrates clinical and developmental perspectives, it is truly international, and interdisciplinary, and it combines high scientific standards with attention to clinical relevance.” Prof. Sir Michael Rutter

http://www.blackwellpublishing.comjournal.asp?ref=0021-9630&site=1

Editor Charman is a contributor to Rutter’s book:-

Rutter’s Child and Adolescent Psychiatry, Fifth Edition

Rutter was also an expert witness in Malmo, Sweden in an MMR autism case where the key question was whether autism was solely genetic and not environmental. Rutter’s expert evidence was that it was genetic [not possible - Autism Not Genetic – Says Expert Professor Simon Baron Cohen ].

And this could go on and on and on ………………….

When confronted with the above evidence on Rutter’s Japanese autism paper Charman refused to have the Honda/Rutter paper retracted or to publish a correction or rebuttal. The publishing group Blackwell which published the Honda/Rutter paper have provided no comment.

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