The results of a parent survey
Stephen T. SchultzUniversity of California San Diego, and San Diego State University, USA, Stephen.schultz@med.navy.mil, stevendri@hotmail.com
Hillary S. Klonoff-Cohen
University of California San Diego, USA
Deborah L. Wingard
University of California San Diego, USA
Natacha A. Akshoomoff
University of California San Diego, USA
Caroline A. Macera
San Diego State University, USA
Ming Ji
San Diego State University, USA
The present study was performed to determine whether acetaminophen
(paracetamol) use after the measles-mumps-rubella vaccination
could be associated with autistic disorder. This case-control
study used the results of an online parental survey conducted
from 16 July 2005 to 30 January 2006, consisting of 83 children
with autistic disorder and 80 control children. Acetaminophen
use after measles-mumps-rubella vaccination was significantly
associated with autistic disorder when considering children
5 years of age or less (OR 6.11, 95% CI 1.42—26.3), after
limiting cases to children with regression in development (OR
3.97, 95% CI 1.11—14.3), and when considering only children
who had post-vaccination sequelae (OR 8.23, 95% CI 1.56—43.3),
adjusting for age, gender, mother's ethnicity, and the presence
of illness concurrent with measles-mumps-rubella vaccination.
Ibuprofen use after measles-mumps-rubella vaccination was not
associated with autistic disorder. This preliminary study found
that acetaminophen use after measles-mumps-rubella vaccination
was associated with autistic disorder.
The results of a parent survey
University of California San Diego, and San Diego State University, USA, Stephen.schultz@med.navy.mil, stevendri@hotmail.com
University of California San Diego, USA
University of California San Diego, USA
University of California San Diego, USA
San Diego State University, USA
San Diego State University, USA
The present study was performed to determine whether acetaminophen (paracetamol) use after the measles-mumps-rubella vaccination could be associated with autistic disorder. This case-control study used the results of an online parental survey conducted from 16 July 2005 to 30 January 2006, consisting of 83 children with autistic disorder and 80 control children. Acetaminophen use after measles-mumps-rubella vaccination was significantly associated with autistic disorder when considering children 5 years of age or less (OR 6.11, 95% CI 1.42—26.3), after limiting cases to children with regression in development (OR 3.97, 95% CI 1.11—14.3), and when considering only children who had post-vaccination sequelae (OR 8.23, 95% CI 1.56—43.3), adjusting for age, gender, mother's ethnicity, and the presence of illness concurrent with measles-mumps-rubella vaccination. Ibuprofen use after measles-mumps-rubella vaccination was not associated with autistic disorder. This preliminary study found that acetaminophen use after measles-mumps-rubella vaccination was associated with autistic disorder.