Synthetase

BRA I and breast cancer by Martin Eastwood Posted Mon 18 Jan 2010 4:51am -conjugating enzymes and is required for its ubiquitin ligase activity. Ligase enzymes catalyse the joining together ofmolecules of two substances and with a breaking of a diphopsatebond in a nucleoside triphosphate. They used to be called synthetase. Many disease-causing mutations are found within this region, and loss of the ligase activity is associated with suscepti Read on »

Glucocorticoid-Remediable Aldosteronism by Matt S. Posted Thu 01 May 2008 12:00am state. The mechanism is pretty cool: the genes for both aldosterone synthetase and 11b-hydroxylase are adjacent genes on the same chromosome which are 95% homologous. Sometimes Read on »

Glutamine and Muscle by Timothy C. Patient Expert

Posted Sat 13 Sep 2008 3:19pm is added to glutamate by the enzyme glutamine synthetase. Glutamine/glutamate is found in great concentration in muscle tissue, gut tissue and blood circulation. There are many Read on »

Unusual Causes of Anion Gap Metabolic Acidosis by Matt S. Posted Wed 13 Aug 2008 12:00am of the antioxidant glutathion, occurs. This may be either genetic (caused by mutations in 5-oxo-prolinase or glutathione synthetase) or acquired (due to Tylenol ingestion, classically Read on »

Prevalence of antibodies to Ro-52 in a serologically defined population of patients with systemic sclerosis by Jan Posted Thu 21 Oct 2010 12:00am of aminoacyl-tRNA synthetase (aats) antibodies. To date there have been no comprehensive reports on the frequency of anti-Ro-52 in systemic sclerosis (SSc), a disease characterised Read on »

Tocolytics in pre term labor by David Smith, MD Posted Mon 05 Oct 2009 10:03pm of this class is nifedipine. These drugs should not be used in women with cardiovascular disease or those who are hemodynamically unstable. Prostaglandin Synthetase Inhibitors: The discovery that prostaglandins play a role in the initiation of labor led to the study of prostaglandin synthetase inhibitors as agents for treating preterm Read on »

Future myeloma treatments… by Margaret Patient Expert

Posted Wed 09 Feb 2011 5:56am a new myeloma target (I think I’ve seen this one before, but I don’t have the energy to check right now…) called “glycogen synthetase kinase-3 beta” (GSK3beta). Well, the above Read on »

What is Primary Hyperaldosteronsim? by Flower Spy Posted Thu 30 Oct 2008 12:00am product that combines the promoter of the 11beta-hydroxylase gene with the coding region of the aldosterone synthetase gene. The type 2 variant of familial PH (which... of the aldosterone synthetase gene (which normally does not have such a promoter). Thus, ambient ACTH levels pathologically overstimulate aldosterone synthesis inappropriately.3 In patients Read on »

Acetaminophen & the kidney by Matt S. Posted Mon 11 Oct 2010 2:46am lead to a depletion of intracellular glutathione stores. This leads to lack of feedback inhibition of gamma-glutamylcysteine synthetase, which in turn leads to a rise in gamma Read on »

Systemic sclerosis: an autoantibody mosaic by Jan Posted Fri 11 Sep 2009 4:55pm are the most common, while antibodies to Jo-1 and other aminoacyl-tRNA synthetases occur infrequently [4]. Of those antibodies with little specificity for SSc, anti-Ro and anti-U1-RNP... synthetase antibodies such as anti-Jo-1 have a high incidence of pulmonary fibrosis in addition to myositis. The severity of the fibrosis is a major factor influencing prognosis Read on »

Synthetase - Articles

Related Searches