Renin - Articles

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What makes the juxtaglomerular apparatus release renin? by pathologystudent Posted Fri 06 Nov 2009 10:02pm Q. What triggers renin release? I know that it’s hypo-filtration of the juxtaglomerular apparatus (i.e. reduced fluid flow) but what is the actual trigger for renin release? A. There are actually three different types of cells in the JGA: granular cells (which secrete renin), macula densa cells (which secrete a vasopressive substance that acts Read on »

Basic Review: The Renin-Angiotensin-Aldosterone Axis by Matt S. Posted Thu 27 Aug 2009 12:00am One of the coolest aspects of the renin-angiotensin-aldosterone system (RAAS) is that it involves multiple organ systems: the liver, lung, adrenal gland, kidney... of action. 1. Renin is a peptide hormone secreted from the juxtaglomerular cells of the afferent arteriole in response to 3 main stimuli: (a) renal hypoperfusion, (b) decreased Read on »

The differential diagnosis of syndromes involving hypokalemia, metabolic alkalosis, and hypertension by Matt S. Posted Sun 13 Dec 2009 12:00am that prevent proper conversion of cortisol into cortisone. 3. Renal artery stenosis and renin secreting tumors. Both of these etiologies are the result of elevated production and secretion of renin leading to hyperaldosteronism. 4. Adrenal hyperfunction. This category includes causes of primary hyperaldosteronism, including adrenal adenoma, adrenal Read on »

Aliskiren by Matt S. Posted Tue 29 Apr 2008 12:00am Are renin inhibitors the next big weapon in the fight against hypertension? As we all know, ACE-I's & ARB's have so many renoprotective effects that there is substantial... of angiotensin converting enzyme (ACE) or the angiotensin receptor (ARB), a new class of direct renin inhibitors of which aliskiren is the current prototype are now being tested. While Read on »

Blood Pressure Test May Help Guide Treatment by Medline Plus Posted Wed 18 Aug 2010 10:44am hormone called renin may help doctors decide which blood pressure drugs their patients should take, researchers said on Wednesday. They said a mismatch between drugs and patient characteristics may help explain why many people do not benefit from blood pressure drugs, and testing for renin levels may help Read on »

Review: The Juxtaglomerular Apparatus by Matt S. Posted Sat 25 Oct 2008 12:00am for regulating both intrarenal (tubuloglomerular feedback) and extrarenal (renin-angiotensin-aldosterone) mechanisms necessary to maintain both renal and entire body volume status. The three components of the JGA are the following (1) the juxtaglomerular cells of the afferent arteriole, synthesize and store renin, which is secreted in response to specific Read on »

Page Kidney by Matt S. Posted Mon 16 Mar 2009 12:00am in elevated renin-angiotensin-aldosterone levels and severe hypertension. Over time, a loss of renal function occurs due to some degree of renal ischemia and constrictive perinephritis... compression of the kidney leads to activation of the renin-angiotensin-aldosterone system resulting in hypertension. The most common cause of a Page kidney is a subcapsular hematoma Read on »

In Some Patients, Hypertension Meds Raise Blood Pressure by Medline Plus Posted Wed 25 Aug 2010 1:00pm the kidney enzyme -- renin -- that is critical to blood pressure control. After monitoring and reviewing both plasma renin activity (PRA) and systolic blood pressure levels during treatment, Alderman and his team found that the plasma renin levels predicted whether a "V" or an "R" drug would benefit or be problematic for a particular patient. Overall, 7.7 Read on »

Key to angiotensin formation solved? Preeclampsia linked to oxidative stress by Matt S. Posted Fri 08 Oct 2010 1:00am Researchers from the UK published a new and exciting article exploring one of the fundamental mechanisms of blood pressure regulation by the renin-angiotensin-system (RAS... here for a review of the RAS from Nate). The first step of this process is the cleavage of angiotensinogen by the enzyme renin to form angiotensin I (Ang I). Precisely how renin Read on »

FDA Approval Given for for Amturnide-Triple Combination Pill to Treat High Blood Pressure in Patients Uncontrolled on Two Medica by Medical Quack Patient Expert

Posted Wed 29 Dec 2010 4:56pm ) approved Amturnide (aliskiren, amlodipine and hydrochlorothiazide) tablets for the treatment of high blood pressure. Amturnide combines the only approved direct renin inhibitor... pressure in three ways. The Tekturna component targets the activity of the renin angiotensin aldosterone system (RAAS), an important regulator of blood pressure. Tekturna directly Read on »

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