Pulmonary Artery - Articles

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Borderline Pulmonary Arterial Pressure Is Associated with Decreased Exercise Capacity in Scleroderma by Jan Posted Sat 19 Mar 2011 10:26pm Rationale: Pulmonary arterial hypertension is associated with impaired exercise capacity and decreased survival in patients with scleroderma. Randomized controlled studies showed significant benefit of targeted therapies in patients with a resting mean pulmonary arterial pressure (MPAP) greater than 25 mm Hg. The clinical relevance Read on »

Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension by Jan Posted Thu 18 Nov 2010 1:55am Pulmonary arterial hypertension (PAH) is a chronic and progressive disease characterized by a persistent elevation of pulmonary artery pressure accompanied by right.... Both vasoconstriction and structural remodeling (enhanced proliferation of vascular smooth muscle cell) of the pulmonary arteries contribute to the progressive course of PAH Read on »

Pulmonary arterial hypertension in systemic sclerosis: the need for early detection and treatment. by Jan Posted Fri 12 Nov 2010 4:36am Pulmonary arterial hypertension (PAH) is an important cause of mortality in systemic sclerosis (SSc). The symptoms are non-specific and can be ascribed to other features... artery pressure >45 mmHg on echocardiography). Right heart catheter remains the diagnostic gold standard. An algorithm for screening with regular pulmonary function tests Read on »

Natriuretic Peptides in Systemic Sclerosis-related Pulmonary Arterial Hypertension by Jan Posted Mon 01 Feb 2010 12:00am By Theodoros Dimitroulas and Colleague Abstract Objectives Systemic sclerosis-related pulmonary arterial hypertension (SSc PAH) is a major complication of both..., and pulmonary arterial hypertension. Results In patients with SSc PAH, NP levels increase in proportion to the extent of right ventricular dysfunction and correlate significantly Read on »

Combination Therapy Likely to Expand in Scleroderma Pulmonary Artery Hypertension by Jan Posted Wed 17 Nov 2010 12:45am MARINA DEL REY, California (EGMN) – Right ventricle catheterization is essential to confirm a diagnosis of pulmonary artery hypertension in patients with systemic sclerosis... artery hypertension (PAH) – is accurate to within 10 mm Hg only half the time, compared with catheterization. More than a quarter of the time, it overestimates pulmonary artery Read on »

Asymmetrical dimethylarginine in systemic sclerosis-related pulmonary arterial hypertension by Jan Posted Fri 11 Sep 2009 4:56pm to pulmonary artery hypertension (PAH). Asymmetrical dimethylarginine (ADMA) is an endogenous nitric oxide (NO) inhibitor. Increased concentrations of plasma ADMA may also contribute...). Systolic pulmonary artery pressure (sPAP) assessed by echocardiography, lung function tests, 6-min walk test (6MWT) and serum ADMA levels were recorded from patients. Results Read on »

Pulmonary arterial hypertension complicating connective tissue diseases by Jan Posted Thu 04 Feb 2010 12:00am Pulmonary arterial hypertension (PAH) may complicate diverse connective tissue diseases (CTDs) such as systemic sclerosis (SSc), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and mixed CTD (MCTD) and is an important cause of morbidity and mortality in this context. From a histological standpoint, the pulmonary vascular lesions Read on »

Determinants of pulmonary arterial hypertension in scleroderma by Jan Posted Fri 12 Nov 2010 4:42am OBJECTIVE: To define risk factors associated with pulmonary arterial hypertension (PAH) in a large cohort of patients with systemic sclerosis (SSc). METHODS: SSc... pulmonary artery pressure along with pulmonary function testing, clinical, and laboratory data. PAH was defined as right ventricular systolic pressure equal or greater than 40 mm Hg Read on »

Identification of Target Antigens of Antifibroblast Antibodies in Pulmonary Arterial Hypertension by Jan Posted Fri 27 Nov 2009 10:03pm By Benjamin Terrier and Colleague Rationale: Pulmonary arterial hypertension (PAH) may be classified as idiopathic (IPAH) or familial (FPAH) or associated with various... to identify the target antigens of AFAs in such patients. Objectives: To identify target antigens of antifibroblast antibodies in pulmonary arterial hypertension. Methods: Sera Read on »

Identification of candidate genes in scleroderma-related pulmonary arterial hypertension. by Jan Posted Wed 17 Nov 2010 1:04am We hypothesize that pulmonary arterial hypertension (PAH)-associated genes identified by expression profiling of peripheral blood mononuclear cells (PBMCs) from patients with idiopathic pulmonary arterial hypertension (IPAH) can also be identified in PBMCs from scleroderma patients with PAH (PAH-SSc). Gene expression profiles of PBMCs collected from Read on »