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Protein Kinase - Articles

Opposing Effects of Protein Kinase Cα and Protein Kinase Cϵ on Collagen Expression by Human Lung Fibroblasts Are Medi by Jan Posted Thu 25 Nov 2010 2:59am The roles of MEK, ERK, the ϵ and α isoforms of protein kinase C (PKC), and caveolin-1 in regulating collagen expression were studied in normal lung fibroblasts. Knocking down caveolin-1 gave particularly striking results. A 70% decrease caused a 5-fold increase in MEK/ERK activation and collagen expression. The combined data reveal a branched sig ... Read on »
Curcumin-induced apoptosis in scleroderma lung fibroblasts: role of protein kinase cepsilon. by Jan Posted Fri 11 Sep 2009 4:57pm Research by Tourkina E. and Colleague. Scleroderma, a disease involving excessive collagen deposition, can be studied using fibroblasts cultured from affected tissues. We find that curcumin, the active component of the spice turmeric, causes apoptosis in scleroderma lung fibroblasts (SLF), but not in normal lung fibroblasts (NLF). This ... Read on »
A Novel Immortalized Human Adrenal Cell Line with Inactive Protein Kinase A for Studies on cAMP Signaling and Endocrine Tumorige by nih.gov Posted Thu 27 Sep 2012 8:00pm Description of Invention: The first known immortalized cell line with a naturally-occurring inactivating mutation in PRKAR1A, the regulatory subunit type 1A (R1alpha) of protein kinase A (PKA), which is associated with tumor formation. PKA isozyme balance is critical for the control of cAMP signaling and related cell cycl ... Read on »
Cooling-induced contraction and protein tyrosine kinase activity of isolated arterioles in secondary Raynaud's phenomenon. by Jan Posted Wed 23 Dec 2009 12:00am OBJECTIVE: To investigate the response of skin arterioles from control subjects and patients with scleroderma and Raynaud's phenomenon (RP/SSc) to cooling and modulators of protein tyrosine kinase (PTK) activity. METHODS: We used the microvessel perfusion technique to characterize the response of isolated dermal arterioles (1 ... Read on »
Use of Anthrax Lethal Factor to Treat Cancer and Screening Methods for MAPK Kinase Protease Activity by nih.gov Posted Sun 01 Aug 2010 5:00pm Description of Invention: Anthrax toxin, produced by Bacillus anthracis, is composed of three proteins; protective antigen (PA), edema factor (EF), and lethal factor (LF). PA by itself has little or no toxic effect upon cells, but serves to bind cell surface receptors and mediate the entry of EF and LF into the cell. EF has be ... Read on »
Modulating P38 Kinase Activity by nih.gov Posted Wed 02 Jun 2010 5:00pm Description of Invention: Protein kinases are involved in various cellular responses to extracellular signals. The protein kinase termed p38 is also known as cytokine suppressive anti-inflammatory drug binding protein (CSBP) and RK. It is believed that p38 has a role in mediating cellular response to inflammatory stimuli, su ... Read on »
PPAR-Delta: Dagger in the Heart of CAD by Dr. B G Doctor of Pharmacy Posted Sun 24 Aug 2008 4:03pm (Proteins = amino acids) PPAR-Delta is part of the family of peroxisome proliferator-activated receptors (PPARs). This receptor family is responsible for cueing in environmental nutrients. In evolutionary terms, survival depended on nutrients in the environment and the ability for the human body to adapt to low nutrients vs ... Read on »
Antisera to Detect Phosphorylated Phosphoinositide-Dependent Kinase 1 (PDK-1) by nih.gov Posted Thu 30 Nov 2006 4:00pm Description of Invention: PDK-1 phosphorylates and activates a number of cellular kinases, and plays a major role in insulin and growth factor signaling. PDK-1 also represents a promising drug target for a number of cancers. Autophosphorylation at Ser244 (mouse) or Ser241 (human) is critical for PDK-1 activity. Availab ... Read on »
Key Proteins Found For Ovulation by Emily Posted Thu 02 Jul 2009 6:31pm A new study in mice, published in the May issue of Science, has identified two key proteins critical for ovulation. The proteins, called extracellular-regulated protein kinases 1 and 2 (ERK 1 and ERK 2), appear to bring about the maturation and release of the egg. "Ovulation results from a complex interplay of chemical sequences," said Duane Alexan ... Read on »
Intestinal Protein May Have Role in ADHD by Jeff H. Patient ExpertHealth Impact Award Posted Mon 22 Aug 2011 12:18pm I love reading about medical breakthroughs like the following, if only ADD/ADHD received more attention on the funding front to drive results like this story — A biochemical pathway long associated with diarrhea and intestinal function may provide a new therapeutic target for treating ADHD (Attention Deficit Hyperactivity Disorder) other neuro ... Read on »