Angiotensin-converting enzyme in systemic sclerosis: from endothelial injury to a geneticpolymorphism.
by
JanPosted
Fri 11 Sep 2009 4:55pm
) polymorphism, consisting of the presence or absence of a 287-base pair Alu sequence, has been identified. This polymorphism has been related to ACE enzyme levels, and data from experimental studies reported a functional role for this polymorphism in modulating the angiotensin II levels.
We previously documented a high ACE D allele frequency in SSc patients
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Geneticpolymorphisms of CYP2D6 oxidation in patients with systemic sclerosis
by
JanPosted
Tue 16 Feb 2010 12:00am
with the evaluation of the genetically determined polymorphism of CYP2D6, one of the phase I drug metabolizing isoenzymes, in patients suffering from SSc. Usefulness of the CYP2D6 genotype... polymorphism was performed with the PCR-RFLP method.
RESULTS:
Relative risk of SSc development for particular genotype carriers expressed by the odds ratio (OR) was statistically
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Oxygen free radical scavenger enzyme polymorphisms in systemic sclerosis
by
JanPosted
Fri 11 Sep 2009 4:56pm
Research byTikly M. and Colleague
We performed a case-control study of polymorphisms of glutathione S-transferase (GST) isoenzymes and manganese superoxide dismutase... in the diffuse cutaneous SSc subset compared with controls (OR=2.11 and 3.15, respectively, p(corr)
<.1). Our findings provide new data on the distribution of GST and MnSOD polymorphismsRead on »
Oxygen free radical scavenger enzyme polymorphisms in systemic sclerosis.
by
JanPosted
Fri 11 Sep 2009 4:59pm
By Tikly M. and Colleague
We performed a case-control study of polymorphisms of glutathione S-transferase (GST) isoenzymes and manganese superoxide dismutase (MnSOD... in the diffuse cutaneous SSc subset compared with controls (OR=2.11 and 3.15, respectively, p(corr)
<.1). Our findings provide new data on the distribution of GST and MnSOD polymorphismsRead on »
Macrophage migration inhibitory factor promoter polymorphisms and the clinical expression of scleroderma
by
JanPosted
Tue 08 Dec 2009 12:00am
By Sou-Pan Wu and Colleague
Objective
To investigate the potential association between functional polymorphisms in the gene for the innate mediator, macrophage... and sex subsets. Significant relationships were determined between clinical variables and MIF polymorphisms for each disease subtype in the studied groups.
Results
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Association Between a CTGF Gene Polymorphism and Systemic Sclerosis in a French Population.
by
JanPosted
Wed 20 Jan 2010 12:00ampolymorphisms (SNP) in the CTGF gene and scleroderma in a French population (registration number 2006/0182).
METHODS:
We conducted a case-control study with 241 scleroderma... the rs9399005 polymorphism in its 3'UTR region. In silico analysis indicated that this polymorphism may alter the structure of CTGF messenger RNA.
CONCLUSION:
These findings
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SGK1 Polymorphisms
by
Matt S.Posted
Tue 10 Mar 2009 12:00am
4-2, which in the absence of SGK1 ubiquitinates and degrades ENac.
How does this relate to human disease? It turns out that there is a common polymorphism within the SGK1 gene.... Carriers of this polymorphism are also prone to develop an elevated BMI and thus this appears to be a key gene regulating metabolic syndrome. Perhaps drugs targeting SGK1
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