Angiotensin-converting enzyme in systemic sclerosis: from endothelial injury to a genetic...
by
Jan
... the key enzyme in the RAS, is the predominant pathway of angiotensin II formation in blood and tissues. In intron 16 of the gene encoding for ACE an insertion/deletion (I/D) polymorphism, consisting of the presence or absence of a 287-base pair Alu sequence, has been identified. This polymorphism has been related to ACE enzyme levels, and data fro ...
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FOXO3A polymorphisms linked to human longevity - again!
by
Dr. Chris P.
... found an allele of FOXO3A associated with long lived Japanese men. So it seemed highly appropriate that I wrote the review for a follow-up paper: Flachsbart et al analyzed 16 polymorphisms in the FOXO3A allele in 1,031 long-lived individuals (95-110 years old, 388 centenarians included) and 731 younger controls. They found that polymorphisms in the ...
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p53 and cancer.
by
Martin Eastwood
This important review discusses this key subject of p53 and cancer aetiology. Whibley et al l2009 p53 polymorphisms: cancer implications Nature Reviews Cancer vol 9, 95-107 The normal functioning of p53 is a potent barrier to cancer. Tumour-associated mutations in TP53, typic ...
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Ethnicity influences genetic susceptibility in COPD
by
COPDsurvivor
... ved to play a determining role as only a relatively small proportion of smokers develop the disease.However, they add: “Studies on the role of candidate genes and their polymorphisms in COPD development have so far produced ambiguous results.”To investigate further, the researchers performed a literature search and identified 20 polymor ...
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Chemotherapy Toxicity Genes
by
Dr. Steve Murphy
... rmacogenomics and chemotherapy. In astudyto be released in the May 15th edition of Blood we have just that.The majorfindingsincludeDuring the induction phaseVitamin D Receptorpolymorphisms were linked with gastrointesinal symptoms (diarrhea, nausea, vomiting) 6.85 times more likely.Polymorphisms in Cytochrome p450-Family 3-subfamily A-number 5, wer ...
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one carbon folate genetics
by
Martin Eastwood
Top of page Genetic polymorphisms in the one-carbon folate pathway have been widely studied in association with a number of conditions. Most of the research has focused on the 677C>T polymorph ...
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Genes for Heart Attack Risk/Prostate Cancer Risk
by
Dr. Steve Murphy
... k are published. The findings raise hope of future therapeutic targets and identification of risks.The first studyimplicates theKALRNgene and an intronic(noncoding) SNP. This polymorphism(change in a gene) was found in almost all Caucasians with early heart attack. What does this mean? Very little so far. The results need to be replicated... But m ...
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We can?t blame the serotonin transporter gene for everything.
by
Dr. Shock
... r prospective study does not support the assumption that paroxetine can cause a prolonged PFA-closure (bleeding) time during paroxetine therapy due to a serotonin transporter polymorphism. Old age, use of platelet inhibitors and a history of gastrointestinal bleeding remain the focus for SSRI-induced bleeding complications.Selective Serotonin Reupt ...
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