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Towards an anti-fibrotic therapy for scleroderma: targeting myofibroblast differentiation and recruitment by Jan Posted Mon 31 May 2010 12:00am By Andrew Leask Background In response to normal tissue injury, fibroblasts migrate into the wound where they synthesize and remodel new extracellular matrix. The fibroblast responsible for this process is called the myofibroblast, which expresses the highly contractile protein alpha-smooth muscle actin (alpha-SMA). In normal tissue rep ... Read on »
Hallmarks of cancer v. 2.0 by Mark Pool, MD Posted Tue 19 Apr 2011 4:57pm In 2000, Douglas Hanahan and Robert Weinberg initially proposed six hallmarks of cancer that form an organizing principle for understanding the remarkable diversity of "cancer."  Their update, " Hallmarks of Cancer: The Next Generation ," was published in the March 4, 2011 issue of Cell. The six hallmarks of cancer are distinctive and co ... Read on »
AMD Update 20: How Fovista Works to Increase Vision in the Treatment of Wet AMD by Irv Arons Healthy Living Professional Posted Thu 28 Jun 2012 4:42pm Because I was denied the opportunity to tell you how the combined therapy works, as told by Dr. Pravin Dugel (see AMD Update 19 ), I decided to take another tack. With the permission of Ophthotech, I would like to explain and illustrate how the combined therapy of anti-VEGF and anti-PDGF works to provide improved vision compared to monotherapy wi ... Read on »
New Study Provides Better Understanding of Alzheimer’s Disease by Bob DeMarco Patient Expert Posted Sat 14 Dec 2013 9:58am This study may also provide a better understanding of the overlap between Alzheimer’s disease and vascular dementia . +Alzheimer's Reading Room Highlights: Found primarily in the blood-brain barrier, pericytes are cells that protect the nervous system from harmful molecules in the blood. USC researchers find that pericyte l ... Read on »
Fat May Fuel Cancer by A4M Worldhealth.net Posted Thu 15 Nov 2012 10:09pm Posted on Nov. 14, 2012, 6 a.m. in Weight and Obesity Cancer Obese - image from Shutterstock The World Health Organization reports that in 2008 th ... Read on »
The Dangers of Mercury in the H1N1 Vaccine by Ginger T. Patient Expert Posted Mon 26 Oct 2009 11:00pm Last night I attended a SAD 75 (a Maine school district) public meeting on the H1N1 response and school vaccine clinics. It was a strange experience for me, as I feel like I had stepped back in time to a day ten years ago when giving mercury to children was no big deal, perfectly safe, just like candy really. I pointed out a number of ... Read on »
Closing the gap: Journal launch ... by Dr. Rubens D. Medical Doctor Posted Tue 14 Oct 2008 4:58am Closing the gap: Journal launch brings together wound-healing knowledge 14 oct 2008--Until now, controversy has existed as to the exact cell type that produces connective tissue growth factor (CTGF), a key protein in the wound healing process. This knowledge gap is closed in a paper featured in the first issue of Fibrogenesis & Tissue Repair, a ... Read on »
Targeting the jagged/notch pathway: a new treatment for fibrosis? by Jan Posted Mon 21 Mar 2011 8:02am There is no treatment for fibrotic disease. TGFβ is known to promote fibrogenesis in vivo and in vitro, however, development of anti-fibrotic strategies targeting the TGFβ axis is problematic owing to the pleitropic nature of TGFβ action. Two recent papers (Kavian et al. 2010; Nyhan et al. 2010) suggest that the jagged/Notch pathway may selective ... Read on »
"No Evidence of Any Link" by Ginger T. Patient Expert Posted Fri 12 Sep 2008 11:30am [UPDATE: This link is becoming quite popular, so I will just start archiving studies that support the vaccine/autism link here. I will be adding the links to the studies to the top section, and I have added about 25 abstracts following Kirby's list.] [FINAL UPDATE: So I have been adding to the list slowly and have 33 studies, and i will k ... Read on »
How does endothelial cell injury start? The role of endothelin in systemic sclerosis by Jan Posted Fri 11 Sep 2009 4:58pm In order to understand the initiators of endothelial injury and how the ensuing vascular dysfunction contributes to the development of systemic sclerosis (SSc), it is necessary to consider the normal biology of the endothelium and of the myriad of biological molecules and biological functions under its control, and to assess which specific proc ... Read on »