Interstitial Lung Disease - Articles

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Pathogenesis of pulmonary fibrosis in systemic sclerosis: lessons from interstitial lung disease by Jan Posted Wed 17 Nov 2010 7:16am Interstitial lung disease is a frequent complication of systemic sclerosis and currently is the leading cause of death. Our ability to predict which individuals are at greatest risk of developing clinically significant, progressive interstitial lung disease remains inadequate. Identification of circulating autoantibodies and other biomarker ... Read on »

Scleroderma Patients with Combined Pulmonary Hypertension and Interstitial Lung Disease by Jan Posted Tue 30 Nov 2010 9:09pm Objective. Most studies differentiate scleroderma associated pulmonary hypertension and interstitial lung disease (ILD) as 2 separate pathological processes, concentrating on one or the other; however, many patients have both conditions. We studied the demographics, clinical features, and prognosis of individuals with both vascular and inte ... Read on »

Childrens Interstitial Lung Disease (chILD): One families story by Bob .. Patient Expert

Posted Mon 07 Jul 2008 7:14pm Interstitial lung disorders are among the least understood in medicine. They are a diverse group. Many with unknown causes. This can lead to confusion and frustration among families looking for answers, as seen in the story that follows. You can help! Additional research is desperately needed. ThechILD Foundationis an organization working t ... Read on »

Interstitial lung disease and gastroesophageal reflux by Jan Posted Sat 19 Dec 2009 12:00am By Alvin J. Ing MB, BS, MD, FRACP Gastroesophageal reflux (GER) has been associated with a number of interstitial lung diseases, including systemic sclerosis and idiopathic pulmonary fibrosis. Systemic sclerosis results in both pulmonary and esophageal manifestations, and studies have shown a correlation, but no causal relation, between G ... Read on »

Cancer in Interstitial Lung Disease by Jan Posted Fri 11 Sep 2009 4:56pm By Tatjana Peroš-Golubičić and Om P. Sharma Abstract Cancer may complicate the course of any interstitial lung disease, including idiopathic pulmonary fibrosis, sarcoidosis, progressive systemic sclerosis (scleroderma), Langerhans cell granulomatosis, asbestosis, and tuberculosis. Nevertheless, how the previous injury in interstitial ... Read on »

Updates on respiratory bronchiolitis/interstitial lung disease by Mark Pool, MD Posted Wed 03 Mar 2010 10:27am Churg, Muller and Wright published a superb update on RB/ILD in the January 2010 Arch Pathol Lab Med which is essential background to Katzenstein's article in Human Pathology on "occult interstitial fibrosis in smokers." Do yourself a favor and just read my summary of the Katzenstein paper (skip the original) in light of the excellent updat ... Read on »

Gastroesophageal Reflux Incites Interstitial Lung Disease in Systemic Sclerosis: Clinical, Radiologic, Histopathologic, and Trea by Jan Posted Tue 07 Sep 2010 12:00am By Romy B. Christmann and Colleague Available online 21 May 2010. Objectives Interstitial lung disease (ILD) is currently the main cause of death in systemic sclerosis (SSc) and has an unknown pathogenesis. Gastroesophageal reflux (GER) has been strongly implicated as a cause of ILD in several lung diseases, including SSc-ILD ... Read on »

Interstitial Lung Disease in Scleroderma by Jan Posted Fri 11 Sep 2009 4:56pm By S. Mehrabi, M.D. Abstract Lung disease is a frequent manifestation in patients with systemic sclerosis, and has replaced renal disease as the leading cause of mortality. The two major types of pulmonary diseases in systemic sclerosis are interstitial lung disease (ILD), occurring in approximately 80% of patients, and pulmonary hypert ... Read on »

Oxidative stress and antioxidants in interstitial lung disease by Jan Posted Wed 17 Nov 2010 9:28pm Purpose of review: The cause of interstitial lung diseases (ILDs) such as lung fibrosis or sarcoidosis is still largely unknown. Pharmacotherapeutic treatment in ILD lacks a firm mechanistic molecular basis. A striking paradox is that ILDs result in a shortage of oxygen and that at the same time reactive oxygen species are responsible for the tis ... Read on »

Anti-fibroblast antibodies from systemic sclerosis patients bind to -enolase and are associated with interstitial lung disease by Jan Posted Fri 27 Nov 2009 10:03pm By Benjamin Terrier and Colleague Objective: To identify target antigens of anti-fibroblasts antibodies (AFAs) in systemic sclerosis (SSc) patients. Patients and methods: In the first part, sera from 24 SSc patients (12 with pulmonary arterial hypertension [PAH] and 12 without) and 36 idiopathic PAH (IPAH) patients, tested in pooled ... Read on »