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Graft Versus Host Disease - Articles

Daclizumab for Graft Versus Host disease by Mark Levin Posted Wed 24 Jun 2009 7:01pm Daclizumab (trade name Zenapax) is a therapeutic humanized monoclonal antibody to the alpha subunit of the IL-2 receptor of T cells. It is used to prevent rejection in organ transplantation, especially in kidney transplants.Daclizumab reduces the incidence and severity of acute rejection in kidney transplantation without increasing the incidenc ... Read on »
Gleevec for graft versus host disease by Mark Levin Posted Thu 17 Dec 2009 8:51am Chronic graft-vs-host disease (GVHD) is the most common complication of allogeneic hematopoietic stem cell transplantation (HSCT). Patients with chronic GVHD can hahe infections and a variety of compications due to multiple abnormalities of their reconstructed immune systems. Infection is the most common cause of death in patients with chronic ... Read on »
Rapamune for Graft Versus Host Disease by Mark Levin Posted Wed 06 Oct 2010 1:42pm Graft-versus-host disease (GVHD) represents a serious complication of allogeneic BMT and remains one of the most difficult challenges for clinicians. Renal Transplantation Rapamune (sirolimus) is indicated for the prophylaxis of organ rejection in patients aged 13 years or older receiving renal transplants. It is off-label for grft versus h ... Read on »
Enbrel for Graft Versus Host Disease by Mark Levin Posted Sun 13 Dec 2009 10:53am Graft-versus-host disease (GVHD) represents a serious complication of allogeneic BMT and remains one of the most difficult challenges for clinicians. ENBREL is a type of protein called a tumor necrosis factor (TNF) blocker. Enbrel has had some effects in case reports but there has not been a prospective study. Enbrel is now in a clinical study: ... Read on »
Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma. by Jan Posted Sat 30 Oct 2010 12:00am Chronic graft-versus-host disease (cGvHD) and systemic sclerosis (scleroderma [SSc]) share clinical characteristics, including skin and internal organ fibrosis. Fibrosis, regardless of the cause, is characterized by extracellular matrix deposition, of which collagen type I is the major constituent. The progressive accumulation of connect ... Read on »
Inhibition of collagen type I synthesis by skin fibroblasts of graft versus host disease and scleroderma patients: Effect of hal by Jan Posted Fri 03 Dec 2010 2:02am The effect of halofuginone (a plant alkaloid) on collagen α1(I) gene expression and collagen synthesis was evaluated in human skin fibroblasts from patients with chronic graft-versus-host disease (cGvHD) or scleroderma and from a normal individual. Halofuginone caused a dose-dependent inhibition in collagen α1(I) gene expression and collagen sy ... Read on »
Grafts vs Host Disease by cancerisnotanoption Posted Mon 14 Dec 2009 12:26pm Things have been getting a little better each day, each day I feel a little stronger and not so blurry tired. I have a lot of limits, so I know when I finish from hours at the clinic that I should take a nap before I go for a walk or try to go out for a bit. I was able to go out around the lake we have yesterday and take a nice walk with everyo ... Read on »
Eyes on the Road; Hands on the Wheel: OSIR, EFII, HEV : Small Cap Stock Analysis : Small Cap Stocks and Penny Stocks For Big Ret by David Granovsky Posted Mon 05 Jul 2010 12:00am What’s it all about? Osiris is utilizing smart marketing technique and business strategy by first dipping their foot into the shallow end of the stem cell therapy pool. They want to treat Heart, Diabetes, GI and joints with their stem cell product “Prochymal” so they are wisely starting by treating graft versue host diseas ... Read on »
Transplant and Autoimmune Therapy Using T-Cells Expressing Programmed Death Ligand-1 (PD-L1) by Posted Sun 19 Sep 2010 5:00pm Description of Invention: Transplant complications (graft rejection and graft-versus-host disease) and autoimmune diseases are primarily caused by T cell immune responses against normal host tissue or transplanted tissues. These disorders can lead to serious complications and may be chronic, debilitating, and fatal. Current ... Read on »
Adult allogeneic haematopoietic stem cell transplantation: a single centre experience in Malaysia by Stem Cells Malaysia Patient Expert Posted Wed 10 Jun 2009 6:46pm An interesting statistical piece...  Gan GG,  Zakaria Z,  Sangkar JV,  Haris AR,  Bee PC,  Chin E,  Teh A. Department of Medicine, Faculty of Medicine, University Malaya Medical Centre, Kuala Lumpur, Malaysia. We analysed the outcome of 104 patients from a single institution who underwent allogeneic haematopoietic stem cell transplanta ... Read on »