GnRH Agonists: Label Change - Increased Risk of Diabetes and Cardiovascular Disease (Update)
by
FDAPosted
Wed 20 Oct 2010 12:30pm
[Posted 10/20/2010]
AUDIENCE: Oncology, Endocrine, Cardiovascular
ISSUE: Gonadotropin-ReleasingHormone (GnRH) agonists will have new... (heart attack, sudden cardiac death, stroke) in men receiving these medications for the treatment of prostate cancer.
BACKGROUND: GnRH agonists are approved to treat
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FDA formalizes warning of cardivascular risks for LHRH agonists
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Dr. Arnon KrongradPosted
Thu 21 Oct 2010 12:00am
as luteinizing hormone-releasing hormone (LHRH) or gonadotropin-releasinghormone (GnRH) agonists to include warnings about risk for cardiovascular disease and diabetes in product labeling for these drugs.
The LHRH agonists are extensively used in management of prostate cancer, most commonly in men receiving radiation therapy for localized or locally advanced disease
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US FDA reviewing the safety of LHRH agonists
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Dr. Arnon KrongradPosted
Mon 03 May 2010 12:00am
) agonists also known as gonadatropin releasing hormone or GnRH agonists is associated with metabolic side effects that include risks for cardiovascular disease and diabetes...:
“Healthcare professionals should be aware of these potential safety issues and carefully weigh the benefits and risks of GnRH agonists when determining treatment.”
“Patients
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Are all LHRH agonists “just the same”?
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Dr. Arnon KrongradPosted
Sat 09 Oct 2010 12:00am
releasing hormone or LHRH agonists (also often referred to as gonadatropin releasing hormone or GnRH agonists) also have “class effects” in that they all lower male testosterone..., it is reasonable to believe that different LHRH agonists may also have different effects in different patients but, as Vilar-González et al. have noted in a recent paper, there is almost
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The luteinizing hormone releasing hormone (LHRH)
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Dr. Arnon KrongradPosted
Wed 17 Sep 2008 1:55pm
Note: The terms “luteinizing hormone” (LH) and “gonadatropin” (Gn) are variously used by different authorities. Thus, LHRH and GnRH are also interchangeable terms in the medical literature. As far as The “New” Prostate Cancer InfoLink is aware, neither term is considered to be “absolutely correct.” We have chosen to use the terms LH and LHRHRead on »
Stress Not Healthly For Fertility
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EmilyPosted
Mon 06 Jul 2009 8:05pm
the production of gonadotropinreleasinghormone ( GnRH ). GnRH stimulates the synthesis and secretion of the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH...) are increased and can directly inhibit GnRH. The study was performed on rats but the researchers believe it may also apply to all mammals. "We know stress affects the top-tier
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Does switching LHRH agonists have a real clinical benefit?
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Dr. Arnon KrongradPosted
Mon 21 Feb 2011 12:00am
There are two potentially good reasons for a patient who is receiving treatment with an LHRH agonist to switch from one product to another: the first is because he is having a problem with the adverse effects of his initial LHRH therapy; the second is because he has a rising PSA on the initial LHRH agonist. However, over the years
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Delayed onset of castration resistance with serum T-based LHRH agonist regimens
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Dr. Arnon KrongradPosted
Fri 07 Jan 2011 12:00am
A new paper just published online in Urology suggests that intermittent and testosterone (T)-based LHRH regimens are less likely to be associated with early onset... forms of LHRH agonist therapy and more complex forms of androgen deprivation therapy (ADT) based on LHRH agonist therapy might have beneficial long-term outcomes compared
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The LHRH “flare” reaction: do we really know what we thought we knew?
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Dr. Arnon KrongradPosted
Wed 30 Dec 2009 12:00am
While it has never been categorically proven that adding an oral antiandrogen like flutamide or bicalutamide (Casodex) to injections of LHRH agonists (e.g., leuprolide actetate) improves overall patient survival, there had been little doubt in people’s minds that giving an antiandrogen for a week or two before a first LHRHRead on »
