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Gleason Score-7 - Articles

The continuing importance of primary Gleason pattern 4 in Gleason 7 prostate cancer by Dr. Arnon Krongrad Medical Doctor Posted Thu 06 Jan 2011 12:00am It has long been understood that men with a Gleason score (GS) of 7 could be divided into two groups: those with Gleason 4 + 3 disease (in which Gleason pattern 4 was more common or “dominant”) and those with Gleason 3 + 4 disease (in which Gleason pattern 3 was dominant). It was first suggested many years ago that Gleason 4 + 3 ... Read on »
Understanding Gleason grading by Dr. Arnon Krongrad Medical Doctor Posted Wed 17 Sep 2008 1:58am Introduction When they are talking about prostate cancer, doctors use the term “grade” to describe the appearance of prostate cancer tissue when it is seen under a microscope. The most common system used in the USA to grade the appearance of this tissue is called the Gleason grading system, after Donald F. Gleason, MD, the physician who fi ... Read on »
Gleason score and risk of death from prostate cancer by Dr. Arnon Krongrad Medical Doctor Posted Sun 28 Sep 2008 7:03pm Based on a reanalysis of prostate cancer data from the Connecticut tumor registry, Albertsen writes in the World Journal of Urology that, “high risk prostate cancer is best identified by Gleason score 7-10.” However, he further concludes that there is no evidence to support the suggestion that “men with high-grade disease are less likely to b ... Read on »
Outcomes in men with Gleason scores of 7 by Dr. Arnon Krongrad Medical Doctor Posted Fri 12 Dec 2008 3:38pm Burdick et al. have carried out a retrospective analysis of data from 705 patients with a pre-treatment biopsy Gleason score of 7 treated at the Cleveland Clinic between 1996 and 2005 to see if there was any difference in the outcomes of patients with a primary Gleason pattern of 3 (i.e., a Gleason score of 3 + 4 = 7) and those with a primary ... Read on »
Is surgery appropriate for men with Gleason 8-10 disease? by Dr. Arnon Krongrad Medical Doctor Posted Fri 12 Dec 2008 3:39pm It is well known that a Gleason score of 8-10 at the time of diagnosis is predictive of less good long-term outcomes in the treatment of prostate cancer. However, it is also well known that many men who present with early stage prostate cancer and a Gleason score of 8-10 do very well following radical surgery. A Spanish group ( Rioja Zuaz ... Read on »
The meaning of tertiary Gleason pattern 5 by Dr. Arnon Krongrad Medical Doctor Posted Fri 12 Dec 2008 3:41pm Trpkov et al. have reported on recent findings related to the significance of a tertiary finding of Gleason pattern 5 prostate cancer in a biopsy core or cores from men diagnosed with prostate cancer of otherwise lower Gleason grade. In other words, what does it mean if a man should be diagnosed as having, for example, Gleason 4 + 3 = 7 disea ... Read on »
An update on Gleason grading system today by Dr. Arnon Krongrad Medical Doctor Posted Wed 06 Jan 2010 12:00am A review by Epstein in an upcoming issue of the Journal of Urology gives a detailed perspective on the current use of the Gleason grading system, with specific emphasis on the “removal” of Gleason patterns 1 and 2 in evaluating overall Gleason scores of biopsy samples and the value of “tertiary” Gleason pattern data. ... Read on »
Brachytherapy outcomes for Gleason 7 patients by primary grade by Dr. Arnon Krongrad Medical Doctor Posted Fri 16 Apr 2010 12:00am A new article from a group in the UK suggests that there is no difference in outcomes between patients with localized disease and with Gleason scores of 4 + 3 = 7 or 3 + 4 = 7 when their PSA is ≤ 10 and they are treated with iodine-125-based, permanent seed brachytherapy. Monroe et al. report data on the outcomes of 187 ... Read on »
Gleason grades 1 and 2 by Dr. Arnon Krongrad Medical Doctor Posted Wed 17 Sep 2008 1:59am In Gleason grades 1 and 2 the cancer cells closely resemble normal prostate cells. They are the least important grades because they occur infrequently in the general population and because they confer a prognostic benefit which is only slightly better than grade 3. Both of these grades are composed by mass; in grade 2 they are more loosely aggreg ... Read on »
Gleason grade 4 by Dr. Arnon Krongrad Medical Doctor Posted Wed 17 Sep 2008 2:00am Gleason grade 4 is probably the most important grade because it is fairly common and because of the fact that if a lot of it is present, patient prognosis is usually (but not always) worsened by a considerable degree. Here also there is a big jump in loss of architecture. For the first time, we see disruption and loss of the normal gland unit. ... Read on »