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Germinal Centers - Articles

Systems biology approach shows MYB and FOXM1 as master regulators of germinal center proliferation by Mark Pool, MD Posted Tue 15 Jun 2010 7:24pm Back from a relaxing stay-cation as well as ASCO meeting-- The June 2010 issue of Molecular Systems Biology has a fascinating study identifying MYB and FOXM1 as "master regulators" of germinal center proliferation in lymph nodes.  Why should we as pathologists care about this? What piqued my curiosity here was a connection with my prev ... Read on »
TWiV 161: Concerto in B by Vincent Racaniello Posted Sun 11 Dec 2011 12:00am Hosts: Vincent Racaniello , Rich Condit ,  Alan Dove ,  and Gabriel Victora Vincent, Rich, Alan and Gabriel review the production of antibodies by B cells, and how high affinity antibodies are selected in the germinal centers of lymph nodes. Please help us by taking our listener survey . Click the arrow above to play, or ... Read on »
Importance of Immunohistochemistry in the Evaluation of follicular lymphoid lesion by Dr.Prashant Jani Patient Expert Posted Wed 04 Nov 2009 10:02pm Before discussing the utility of particular immunostains, it is important to review and understand some basics about the normal lymphoid follicle, in order to interpret the immunostains appropriately. The difference between a primary follicle and a secondary follicle: A primary or "resting" follicle: - a collection of B-cells in the cortex ... Read on »
Starry-sky pattern by pathologystudent Posted Sun 14 Nov 2010 10:52am There are a few terms in pathology that should automatically make you think of specific diseases. In hematopathology, “cerebriform lymphocyte” should make you think of Sezary syndrome/mycosis fungoides; “hypersegmented neutrophil” should bring to mind megaloblastic anemia, and the crude but descriptive “butt cell” should summon up follic ... Read on »
Importance of Immunohistochemistry in the Evaluation of follicular lymphoid lesion by Dr.Prashant Jani Patient Expert Posted Fri 22 May 2009 10:40pm Before discussing the utility of particular immunostains, it is important to review and understand some basics about the normal lymphoid follicle, in order to interpret the immunostains appropriately. The difference between a primary follicle and a secondary follicle: A primary or "resting" follicle: - a collection of B-cells in the cortex of ... Read on »
Importance of Immunohistochemistry in the Evaluation of follicular lymphoid lesion by Dr.Prashant Jani Patient Expert Posted Mon 06 Apr 2009 5:58am Before discussing the utility of particular immunostains, it is important to review and understand some basics about the normal lymphoid follicle, in order to interpret the immunostains appropriately. The difference between a primary follicle and a secondary follicleA primary or "resting" follicle: - a collection of B-cells in the cortex of th ... Read on »
Part 3. Molecular testing in lymphoma: USCAP 2010 by Mark Pool, MD Posted Mon 26 Apr 2010 8:00am Final recap from Dr. Adam Bagg's lecture at USCAP 2010 on molecular testing in lymphoma.  The highpoint of the lecture for me was his comments on diffuse large B-cell lymphoma (DLBCL) since this is the most common lymphoma type we see in our practice.  It so happens that there have been some recent papers that I've read that complement Dr. B ... Read on »
THE CASE FOR CHRONIC INFECTION by Joanne60 Posted Mon 06 Sep 2010 4:02am The Case For Chronic Infection: Evidential persistence of Borrelia species post antibiotic exposure in vivo and in vitro. https://acrobat.com/#d=sbb-EmpQrQTgrPoezLGreg Michael D. Parent Introduction Summary There is an abundance of evidence demonstrating that Borrelia Burgdorferi, the causative agent of Lyme Disease, and related patho ... Read on »
Lyme Disease Symptom Checklist by Bryan R. Patient Expert Posted Wed 30 Nov 2011 7:42pm LYME DISEASE SYMPTOM CHECKLIST James Schaller, M.D., M.A.R. The following checklist is not meant to be complete or authoritative. Information about Lyme disease is constantly emerging and changing. Therefore any checklist is intended for use as a starting point. In traditional medicine, a physician performs a complete history and physical. ... Read on »
Genetic Depletion of Complement Receptors CD21/35 Prevents Terminal Prion Disease in a Mouse Model of Chronic Wasting Disease by Terry S. Patient Expert Posted Thu 27 Sep 2012 5:53pm Genetic Depletion of Complement Receptors CD21/35 Prevents Terminal Prion Disease in a Mouse Model of Chronic Wasting Disease Brady Michel*, Adam Ferguson*, Theodore Johnson*, Heather Bender*, Crystal Meyerett-Reid*, Bruce Pulford*, Adriana von Teichman†, Davis Seelig*, John H. Weis‡, Glenn C. Telling*, Adriano Aguzzi† an ... Read on »