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Where does von Willebrand Factor come from? by pathologystudent Posted Wed 04 Nov 2009 10:05pm Q. I have a question about von Willebrand Factor – where is it stored? All that I can gather is that it’s stored in ‘Weibel-Palade bodies’, but where are they? Are they in the vessel wall, in the platelet, free-floating in the blood? It’s confusing me a little bit. A. First, a little background. Von Willebrand Factor is a huge multimeric p ... Read on »
VON Willebrand Disease by Noman Khan Posted Tue 23 Jun 2009 6:54pm What Is von Willebrand Disease? Von Willebrand disease (VWD) is a bleeding disorder. It affects your blood's ability to clot. If your blood doesn't clot, you can have heavy, hard-to-stop bleeding after an injury. The bleeding can damage your internal organs or even cause death, although this is rare. In VWD, you either have ... Read on »
How do you diagnose hemophilia? by pathologystudent Posted Thu 11 Feb 2010 8:36am Q. In one of my other courses, the professor was discussing hemophilia. He states that the prothrombin time (PT) is normal, the partial thromboplastin time (PTT) is abnormal, the bleeding time is normal, and patients will not have petechiae. I was wondering how there can be no petechiae and a normal bleeding time in a patient with hemoph ... Read on »
USA Blood products, collected from a donor who was at risk for vCJD, were distributed July-August 2010 by Terry S. Patient Expert Posted Thu 12 Aug 2010 7:58am PRODUCT Source Plasma. Recall # B-1751-10 CODE Units: 4940074276, 4940073715, 4940071471, 4940069659, 4940069033, 4940067949, 4940067284, 4940066697, 4940066186, 4940065501, 4940065059, 4940064400, 4940063689, 4940063201, 4940062301, 4940061045, 4940060118, 4940059432, 4940058612, 4940058035, 4940057327, 4940056944, 4940056102, 4940055531, 494005 ... Read on »
Minirin side effecst by heroteo heroteo Posted Mon 06 Sep 2010 6:50pm HomeParkinson’s DiseaseImproving CareCommunityHow to HelpAbout UsDonate Now: minirin and blood pressure - Jump to content 0 unread notifications Signed in as teokimhoe My ProfileMy SettingsMy ContentManage FriendsManage Ignored Users Sign OutHelpSearch This topicSearch section: This topic This forumForumsMembersHelpCalendar Advan ... Read on »
DDAVP and von Willebrand disease by pathologystudent Posted Mon 22 Nov 2010 10:39pm Q. I’m confused about DDAVP. Why do you use it in von Willebrand disease? I read that it raises VIII and VWF, but that doesn’t really make sense since the factor VIII is already there, there is no need to make more of it? Right? The issue isn’t lack of factor VIII but lack of vWF, which carries the factor VIII. A. DDAVP ( ... Read on »
Why do you need the intrinsic pathway when you have the extrinsic pathway? by pathologystudent Posted Mon 07 Mar 2011 5:05pm Q. I understand that hemophilia is caused by factor VIII or IX deficiency and both factors work in the intrinsic pathway. But in patients who are missing factors VIII or IX, isn’t there still the extrinsic pathway that can activate factor X to convert fibrinogen to fibrin? Please help. A. Great question! You are absolutely corre ... Read on »
Noninvasive Control of Uremic Bleeding by Matt S. Posted Sun 29 May 2011 4:42pm We frequently receive requests to dialyze patients with moderate renal failure who are bleeding due to the concern that uremia may be contributing to failure to control blood loss. Patients with renal failure do have an increased tendency to bleed, usually manifested by prolonged bleeding time. I was recently reminded by one of my colleagues ... Read on »
More real student questions about hematopathology by pathologystudent Posted Fri 18 Nov 2011 6:38pm   Q. Does medullary expansion mainly happen in alpha thalassemia patients because they cannot make any useful hemoglobin due the the absence of the alpha chain? Or does it occur in both alpha and beta thalassemias? A. Medullary expansion can happen in severe thalassemia of either alpha or beta type. Patients have a severe anemia ... Read on »
Guidance for Industry Draft Guidance for Industry: Amendment to “Guidance for Industry: Revised Preventive Measures to Red by Terry S. Patient Expert Posted Mon 11 Jun 2012 6:17pm Guidance for Industry Draft Guidance for Industry: Amendment to “Guidance for Industry: Revised Preventive Measures to Reduce the Possible Risk of Transmission of Creutzfeldt-Jakob Disease and Variant Creutzfeldt-Jakob Disease by Blood and Blood Products”             IN SHORT ; “However, based on animal ... Read on »