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Endothelial Cells - Articles

IgG antiendothelial cell autoantibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells by Jan Posted Mon 07 Dec 2009 12:00am D Carvalho and Colleague IgG autoantibodies that bind human endothelial cells (AECA) were detected by ELISA in 30 of 42 samples of sera from patients with scleroderma. Pretreatment of human umbilical vein endothelial cells with AECA-positive scleroderma sera, or IgG purified from these sera, led to a dose- and time-dependent increase in t ... Read on »
Endothelial Cells, Blood Pressure & Dark Chocolate by Cindy M. Patient Expert Posted Mon 22 Sep 2008 11:05am I love research that confirms the value of chocolate. Dark chocolate is my favorite, by the way, and a recent article in the American Journal of Clinical Nutrition (July 2008) by researchers from Yale gives the nod to dark chocolate as improving endothelial cell function and reducing blood pressure in overweight adults. For those of you who to ... Read on »
Endothelial Cells, Blood Pressure & Dark Chocolate by Cindy M. Patient Expert Posted Wed 22 Oct 2008 4:46pm I love research that confirms the value of chocolate. Dark chocolate is my favorite, by the way, and a recent article in the American Journal of Clinical Nutrition (July 2008) by researchers from Yale gives the nod to dark chocolate as improving endothelial cell function and reducing blood pressure in overweight adults. For those of ... Read on »
How does endothelial cell injury start? The role of endothelin in systemic sclerosis by Jan Posted Fri 11 Sep 2009 4:58pm In order to understand the initiators of endothelial injury and how the ensuing vascular dysfunction contributes to the development of systemic sclerosis (SSc), it is necessary to consider the normal biology of the endothelium and of the myriad of biological molecules and biological functions under its control, and to assess which specific proc ... Read on »
Garlic inhibits free radical generation and augments antioxidant enzyme activity in vascular endothelial cells by Jan Posted Wed 18 Nov 2009 10:03pm By Zhihua Wei M.D., M.S. and Benjamin H. S. Lau M.D., Ph.D. Oxygen free radicals have been implicated in mediating various pathological processes such as ischemia, inflammatory diseases, diabetes, and atherosclerosis. The antioxidant enzymes—superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX)—play an important role in sc ... Read on »
Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and endothelial cell apoptosis in immune-mediated vas by Jan Posted Fri 27 Nov 2009 10:03pm By Paola Margutti and Colleague Although detection of autoantibodies in the peripheral blood from patients with immune-mediated endothelial dysfunctions has so far failed to provide tools of diagnostic or pathogenetic value, putative bioindicators include anti-endothelial cell antibodies, a heterogeneous family of antibodies that react with aut ... Read on »
A Gene Expression Signature Identifying Pro-Angiogenic Genes in Ovarian Tumor Endothelial Cell Isolates by nih.gov Posted Thu 31 May 2007 5:00pm Description of Invention: Cancer is a heterogeneous disease that requires multimodality therapy. Most of the therapeutic approaches for ovarian cancer have focused on chemotherapy, which primarily targets proliferating tumor cells. Women with ovarian cancer are typically asymptomatic and they are often diagnosed at an advanc ... Read on »
The Assessment of Anti–Endothelial Cell Antibodies in Scleroderma-Associated Pulmonary Fibrosis by Jan Posted Wed 17 Nov 2010 9:13pm A Study of Indirect Immunofluorescent and Western Blot Analysis in 49 Patients With Scleroderma by Raghav Wusirika and Colleague. We recently reported on the use of an indirect immunofluorescent method designated the rodent lung assay; this test assesses for the presence of circulating antibodies directed at components of the microvasculatu ... Read on »
Effects of Flavonoid-Rich Beverages on Prostacyclin Synthesis in Humans and Human Aortic Endothelial Cells: Association with Ex by Jan Posted Thu 25 Nov 2010 7:40am Diets rich in flavonoids have been associated with reduced risk for cardiovascular disease. This may be due, in part, to flavonoid-induced alterations in eicosanoid synthesis. Our objective was to identify plant-derived beverages that alter synthesis of prostacyclin in cultured human aortic endothelial cells (HAEC), and to determine if these beve ... Read on »
Modulation of the Angiogenic Phenotype of Normal and Systemic Sclerosis Endothelial Cells by Gain-Loss of Function of Pentraxin by Jan Posted Sun 13 Mar 2011 12:26pm Objective. Studies have shown that in systemic sclerosis (SSc) endothelial cells, overproduction of matrix metalloproteinase 12 (MMP-12) and pentraxin 3 (PTX3) is associated with defective angiogenesis. This study was undertaken to examine whether overexpression of the relevant molecules could inhibit angiogenesis of normal microvascular en ... Read on »