Diuretic effects
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Matt S.Posted
Tue 16 Sep 2008 12:00amDiuretics act at the apical surface of specific segments of the renal tubular epithelium.
Question: how do diuretics get to the apical surface?
One could imagine several such scenarios, such as diuretics getting filtered at the glomerulus and then traveling downstream through the urine to its specific site. This is not the case, however
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Diuretics and Fracture Risk in Women
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Northcoast FootcarePosted
Wed 04 Nov 2009 10:06pm
A study in the current issue of the Archives of Internal Medicine evaluated data from the Women’s Health Initiative (1992-1998) for an association between loop diuretics and fracture rate, falls and bone mineral density. The study included 133,855 women (3411 users and 130, 444 nonusers of loop diuretics) who were followed for a mean of 7.7 years
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Prolonged Use of Loop Diuretics ...
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Dr. Rubens D.Posted
Mon 02 Feb 2009 11:45pm
Prolonged Use of Loop Diuretics May Raise Fracture Risk
Medications are normally used by women already at risk for fractures
30 jan 2009-- Postmenopausal women who use loop diuretics are at increased risk of fractures, according to a report published in the Jan. 26 issue of the Archives of Internal Medicine.
Laura D. Carbone, M.D.
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Thiazide Diuretics
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Matt S.Posted
Sat 28 Nov 2009 12:00am
There is a good review article in this month's NEJM entitled "Use of Diuretics in Patients with Hypertension" by Ernst and Moser which focuses predominantly on the thiazide class of diuretics. The thiazides are considered a FUNCTIONAL rather than a STRUCTURAL class of medications--that is, not all compounds considered thiazides have the same
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Information for Those Being Treated for High Blood Pressure with Thiazide Diuretics
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Mellanie H.Posted
Thu 19 Feb 2009 6:31pm1 Comment
Since many who have atrial fibrillation also have high blood pressure, this interesting new study out of Vanderbilt University Medical Center may be of value to know about.
This study finds that, contrary to the current U.S. hypertension guidelines, thiazide diuretics need to be combined with “potassium-sparing” drugs to reduce sudden cardiac death risk
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Beware the Side Effects of Diuretics
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Chris ..Posted
Wed 14 Apr 2010 2:28pm
I’ve been on my diuretic for over a week. I can feel the effects like my rings are looser on my fingers. Good-bye, water weight gain!
Over all, it’s been fine. I have... dehydrated. I am concerned, however, about minerals in my blood.
My doctor did a profile before she put me on the meds. Everything came back normal. The concerns regarding diureticsRead on »
Potassium-Sparing Diuretics
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Matt S.Posted
Tue 26 May 2009 12:00am
The potassium-sparing diuretics consist of the following 4 medications--only some of which (spironolactone & eplerenone in the list below) are structurally similar... within collecting duct cells decreases the activity of apical ENac, thereby preventing Na reabsorption and K excretion. Although spironolactone on its own has a weak diureticRead on »
Diuretics in acute decompensated heart failure – evidence?
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Matt S.Posted
Mon 14 Mar 2011 1:37pm
A randomized controlled trial of loop diuretics was published in NEJM two weeks ago . The trial involved 308 patients, from 26 clinical sites. The details are below:
Type... failureHistory of chronic heart failure and receipt of an oral loop diuretic for at least 1 month before hospitalization, at a dose between 80 mg and 240 mg daily in the case of furosemide
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Expensive New Blood Pressure Meds No Better Than Generic Diuretics
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Ed H.Posted
Sat 14 Aug 2010 1:27pm
Expensive brand-name medications to lower blood pressure are no better at preventing cardiovascular disease than older, generic diuretics, according to new long-term data... examined the comparative value of different blood pressure-lowering medications.
More than 33,000 patients with high blood pressure were randomly assigned to take either a diureticRead on »
Thiazide diuretics: Treatment of choice for high blood pressure?
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Dr. William D.Posted
Wed 07 Jan 2009 2:59pm
Thiazide diuretics are a popular first-line treatment for hypertension among the primary care set.
This practice became especially well-established with the 2002 publication of the ALLHAT Study (Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs DiureticRead on »
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