Cutaneous Leishmaniasis

Microscopic polyangiitis presenting as pulmonary–renal syndrome in a patient with long-standing diffuse cutaneous systemic by Jan Posted Mon 14 Mar 2011 10:47am -inflammatory and only rarely has a vasculitis been reported . Those patients in whom vasculitis has been diagnosed tended to have the limited cutaneous variant of SSc and features... evident vasculitis has been reported. Two cases of diffuse cutaneous SSc associated with a pANCA-positive pulmonary–renal syndrome, a condition consisting of acute nephritis Read on »

A scleroderma-like cutaneous syndrome associated with a marked Th2-type immune response occurring after a prosthetic joint impla by Jan Posted Sun 20 Mar 2011 9:23am A scleroderma-like cutaneous syndrome, occurring after implantation of a prosthetic knee joint in an elderly woman, is reported. This case did not seem to typically fit into any of the known scleroderma-like disorders of the skin described to date. The patient was shown to be sensitized to metals contained in the prosthesis and to mount a Th2-type Read on »

Peroxisome Proliferator-Activated Receptors (PPARs) and the Human Skin: PPARs in Scleroderma and Cutaneous Fibrosis by Jan Posted Mon 14 Mar 2011 10:54am In scleroderma, lesional fibroblasts are responsible for the development of tissue fibrosis. PPARγ is expressed and fully functional in quiescent normal skin fibroblasts. Whereas ligand activation of cellular PPARγ resulted in modest suppression of basal collagen gene expression, it abrogated transforming growth factor-β (TGFβ)-induced stimulatio ... Read on »

Drug Slows Progression of Cutaneous T-Cell Lymphoma by Cancer.gov Posted Tue 30 Mar 2010 9:00pm Drug Slows Progression of Cutaneous T-Cell Lymphoma Adapted from the NCI Cancer Bulletin, vol. 7/no. 6, March 23, 2010 ( see the current issue ). In a randomized trial of denileukin diftitox (ONTAK) for the treatment of cutaneous T-cell lymphoma (CTCL), a type of non-Hodgkin lymphoma that begins Read on »

Trick of the Trade: Topical anesthetic cream for cutaneous abscess drainage in children by Michelle Lin Medical Doctor

Posted Wed 16 Mar 2011 12:00am % lidocaine cream (LMX 4) was associated with spontaneous cutaneous abscess drainage in children. Study Design: Retrospective chart review of children presented with skin... cutaneous abscess drainage in children. Amer J Emerg Med. 2010 - in press. PMID: 21129885 Read on »

Pentoxyphylline in association with vitamin E reduces cutaneous fibrosis in systemic sclerosis by Jan Posted Sat 13 Feb 2010 12:00am Systemic sclerosis (SSc) is a disorder characterized by skin thickness and vasculopathy. The objective of the study was to evaluate the therapeutic effect and safety of the association of pentoxyphylline and vitamin E in SSc patients. Twelve SSc patients (American College of Rheumatology criteria) enrolled this 24-week open-label study. ... Read on »

Cutaneous lupus by Romelette L. Patient Expert

Posted Thu 06 Aug 2009 10:13pm Because I am so focus on my SLE, I forgot that there are two other kinds of lupus. The one is the drug induced lupus and the other one is cutaneous lupus. The kind of lupus that attack the skin. And I think it’s the kind of lupus that is very much active right now in my body (I’ll be the husband’s tuxedo shirt on it). I know it’s my fault my my lupus Read on »

Reactive oxygen species from smooth muscle mitochondria initiate cold-induced constriction of cutaneous arteries by Jan Posted Mon 07 Dec 2009 11:03pm By S. R. Bailey and Colleague Cold constricts cutaneous blood vessels by selectively increasing the activity of smooth muscle 2-adrenoceptors (2-ARs). In mouse tail arteries, 2-AR constriction is mediated by 2A-ARs at 37°C, whereas the cold-induced augmentation in 2-AR activity is mediated entirely by 2C-ARs. Cold causes translocation Read on »

Romidepsin Reduces Disease Burden and Skin Symptoms in Patients with Previously Treated Cutaneous T-Cell Lymphoma by Cancer.gov Posted Sun 07 Nov 2010 9:00pm Romidepsin Reduces Disease Burden and Skin Symptoms in Patients with Previously Treated Cutaneous T-Cell Lymphoma Summary In a clinical trial, romidepsin (Istodax®), a type of targeted therapy called a histone deacetylase inhibitor , reduced the symptoms and tumor burden of cutaneous T-cell lymphoma in many Read on »

Cytokine and chemokine levels in systemic sclerosis: relationship with cutaneous and internal organ involvement by Jan Posted Thu 21 Oct 2010 12:00am Systemic sclerosis (SSc) is a connective tissue disorder characterized by excessive collagen deposition in the skin and internal organs. Several cytokines and chemokines have been implicated in the induction of fibrosis, but a definitive relationship between specific cytokines and organ involvement has not been established yet. Serum sam ... Read on »

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