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Causes Of Adpkd - Articles

New potential drug targets in ADPKD by Matt S. Posted Wed 08 May 2013 12:00am Currently there is no good treatment for the most common inherited cause of ESRD, adult polycystic kidney disease. There have been a number of high profile trials in ADPKD in recent years. These trials have endeavored to show a reduction in cyst growth and GFR decline with everolimus , sirolimus ) and most recently Tolvaptan ( TEMPO ... Read on »
Can Polycystic Kidney Disease Cause Death - PKD Treatment by Pkd Z. Facebook Posted Sat 14 Dec 2013 8:11am Can Polycystic Kidney Disease cause death? Once you or you loved ones are diagnosed with PKD, you must concern the answer of this question. According to different inherited ways, PKD is divided into ARPKD and ADPKD. Both of them are life-threatening and can cause death. Knowing the causes and relative managements is able to prolong your life expe ... Read on »
PKD Molecular Genetic Analysis by Matt S. Posted Fri 06 Jun 2008 12:00am Autosomal Dominant Polycystic Kidney Disease (ADPKD) is caused by the autosomal dominant transmission of mutations in one of two genes identified thus far: PKD1 (which accounts for about 85% of all cases and encodes for the polycystin-1 protein) and PKD2 (which accounts for about 15% of all cases and encodes for the polycystin-2 protein). ... Read on »
Chronic Pain in ADPKD by Matt S. Posted Sat 09 May 2009 12:00am About 60% of all ADPKD patients are estimated to have a chronic pain syndrome, and often this is the initially presenting symptom of an ADPKD patient that brings them to medical attention. An excellent review of this field can be found in a 2001 Kidney Internal article by Bajwa et al . There are many potential reasons for ADPKD patients to ... Read on »
PD – causes of blood in the dialysate by Matt S. Posted Fri 04 Mar 2011 6:00pm A recent post got me thinking of the differential diagnosis of blood-stained peritoneal dialysis effluent. I thought it would be interesting to share some of the differentials and to remember that the Tenchkoff catheter can truly be a window to the abdominal cavity. Blood-stained PD fluid can be dramatic and frightening for both patient and d ... Read on »
Two-Hit Hypothesis & ADPKD by Matt S. Posted Fri 08 May 2009 12:00am One of the really interesting aspects of autosomal dominant polycystic kidney disease (ADPKD) is that only about 1% of all nephrons form cysts. You can do the math: if you have about 1 million nephrons per kidney, and 1% of those nephrons are affected, then you will develop about 10,000 cysts per kidney. The reason these patients often go o ... Read on »
Rapamycin for ADPKD? by Matt S. Posted Wed 08 Jul 2009 12:00am Another potentially useful drug to prevent cyst growth in autosomal dominant polycystic kidney disease comes from the interesting observation that kidney transplant patients with native ADPKD kidneys who were given an immunosuppressant regimen containing the drug rapamycin (sirolimus) displayed less cyst growth than those who did not receive rap ... Read on »
How Does PKD Cause High Blood Pressure by Pkd Z. Facebook Posted Sat 14 Dec 2013 8:30am   Some PKD patients complain their blood pressure increases quickly after the diagnosis of kidney problem. PKD (Polycystic Kidney Disease) is a genetic kidney disorder that characterized by lots of fluid collection in kidney. So will it elevate blood pressure? And how does PKD cause high blood pressure? http://www.pkdclinic.org/pkd-symptoms/23 ... Read on »
The Causes of Fatigue in PKD Patients by Pkd Z. Facebook Posted Fri 24 Jan 2014 6:04am Many PKD patients may feel fatigue easily and can not do normal work. When more and more kidney functions are damaged, fatigue will become more serious. What are the causes of fatigue in PKD patients? http://www.pkdclinic.org/pkd-symptoms/1093.html  Read on »
Can PKD Cause Renal Failure by Pkd Z. Facebook Posted Tue 28 Jan 2014 8:23am Can PKD, or Polycystic Kidney Disease cause renal failure? This is the concerned problem of most PKD patients. Follow me to find the answer with this doubt. http://www.pkdclinic.org/pkd-overview/1103.html  Read on »