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Modulation of Regulatory T-Cell and B-Cell Lymphocytes for the Treatment of Autoimmune and Other Disease Indications by nih.gov Posted Thu 27 Sep 2012 8:00pm Description of Invention: A method of modulating the immune response by affecting the activity of the regulatory lymphocytes through targeting of the Hepatitis A Virus receptor 1 (HAVCR1) receptor. This methodology can be developed for the treatment of autoimmune diseases, allergies, prevention of transplant rejection, and in ... Read on »
B-cell Surface Reactive Antibodies for the Treatment of B-Cell Chronic Lymphocytic Leukemia by nih.gov Posted Sun 11 Oct 2009 5:00pm Description of Invention: B-cell chronic lymphocytic leukemia (B-CLL) is a cancer characterized by a progressive accumulation of functionally incompetent lymphocytes. Despite high morbidity and mortality, the only available potential cure is allogeneic hematopoietic stem cell transplantation (alloHSCST). However, there is le ... Read on »
T Cells, B Cells, Polarized Immune Response in Fibrosis, Systemic Sclerosis: T cells and Polarized Responses by Jan Posted Sat 30 Oct 2010 12:00am T cells and Polarized Responses Almost three decades ago, microscopic and ultrastructural studies in early scleroderma skin revealed the presence of inflammatory cells, including T cells, preceding the deposition of extracellular matrix and the ultrastructural modifications typical of SSc endothelial cells. The presence of T cells in tiss ... Read on »
T Cells, B Cells, and Polarized Immune Response in the Pathogenesis of Fibrosis and Systemic Sclerosis by Jan Posted Fri 04 Dec 2009 12:00am By Carlo Chizzolini Abstract Purpose of Review: A better comprehension of the interactions between cells of the adaptive immune system with fibroblasts and endothelial cells is required to understand abnormal extracellular matrix deposition, development of pathologic fibrosis, and vasculopathy. Recent Findings: Skin T cells wi ... Read on »
Increased Therapeutic Effectiveness of Immunotoxins That Use Toxin Domains Lacking Both T-cell and B-cell Epitopes by nih.gov Posted Tue 07 Feb 2012 7:00pm Description of Invention: Immunotoxins can kill cancer cells while allowing healthy, essential cells to survive. As a result, patients receiving an immunotoxin are less likely to experience the deleterious side-effects associated with non-discriminate therapies such as chemotherapy or radiation therapy. Unfortunately, the cont ... Read on »
Ugly Cell: Diffuse Large B-Cell Lymphoma in the Brain by Dr. Brian M. Medical DoctorHealth Maven Posted Mon 26 Jan 2009 3:49pm A 69-year-old woman presented with a brain mass that was thought to be a primary brain tumor. Instead, our diagnosis turned out to be Diffuse Large B-Cell Lymphoma, Anaplastic Type. This is not a lymphoma that is restricted to the central nervous system; but thus far in this patient the malignancy has only shown up in the brain. A representative ph ... Read on »
Just how many B-cell lymphomas are there? by pathologystudent Posted Thu 14 Apr 2011 7:34pm Q. Can you explain a bit about the classification of B-cell lymphoma? I’m a teacher, and I’ve inherited a lecture on lymphomas. The previous lecturer’s PowerPoint says there are three types of B-cell lymphoma: 1. Small-cell B-cell lymphoma, 2. Large-cell B-cell lymphoma, and 3. Mixed cell type B-cell lymphoma. Have the names of these subt ... Read on »
Revlimid for refractory relapsed B-cell lymphoma by Mark Levin Posted Wed 24 Jun 2009 7:01pm Revlimid is promising for CLL. Revlimid is an orally administered derivative of thalidomide, which is a very active agent for the treatment of multiple myeloma but has serious side effects, especially thromboembolism. Revlimid is reported to have less toxicity than thalidomide but retains antimyeloma effects. Revlimid has recently been appro ... Read on »
Increased Therapeutic Effectiveness of Immunotoxins That Use Toxin Domains Lacking Human B-cell Epitopes by nih.gov Posted Thu 26 Jul 2012 8:00pm Description of Invention: Immunotoxins kill cancer cells while allowing healthy, essential cells to survive. As a result, patients receiving an immunotoxin are less likely to experience the deleterious side-effects associated with non-discriminate therapies such as chemotherapy or radiation therapy. Unfortunately, the continue ... Read on »
CWD infected deer B cells and platelets harbor prion infectivity in the blood by Terry S. Patient Expert Posted Fri 19 Mar 2010 11:25am J. Virol. doi:10.1128/JVI.02169-09 Copyright (c) 2010, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. B cells and platelets harbor prion infectivity in the blood of CWD–infected deer. Candace K. Mathiason, Jeanette Hayes-Klug, Sheila A. Hays, Jenny Powers, David A. Osborn, Sallie J. Dahmes, Ka ... Read on »