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Autoantibodies - Articles

Detection of Plasma Autoantibodies to Brain Tissue in Young Children with and without Autism Spectrum Disorders by Kev Leitch Healthy Living ProfessionalHealth Maven Posted Thu 24 Mar 2011 7:21pm Researchers at the MIND Institute published studies in the past few years correlating antibodies to brain tissue and autism. The first study of this sort (that I recall) studied whether the mother had antibodies to fetal brain tissue: Autism: maternally derived antibodies specific for fetal brain proteins. Other studies have looked at autoan ... Read on »
Comment on: Maternal autoantibodies are associated with abnormal brain enlargement in a subgroup of children with autism spectru by Kev Leitch Healthy Living ProfessionalHealth Maven Posted Tue 12 Feb 2013 5:34pm In 2008 a paper opened up a new area of research in autism risk factors: Autism: maternally derived antibodies specific for fetal brain proteins . The researchers at the U.C. Davis MIND Institute found that for a subset of autistic kids, they could find antibodies in the mothers’ sera that reacted to human fetal brain tissue. Other teams have ... Read on »
Autoantibody and idiotype profile of lung involvement in autoimmune rheumatic disease by Jan Posted Thu 12 Nov 2009 10:03pm By Jones, M. and Colleague Autoimmunity occurs when antibodies, known as autoantibodies, are made against bodily tissues that should not be recognized as foreign. Autoantibodies that are specific to certain types of cells have been found to be associated with particular symptoms of autoimmune disease, such as lung involvement. A study was ... Read on »
Autoantibodies against PDGF Receptor in Scleroderma by Filemon K. Tan by Jan Posted Fri 11 Sep 2009 4:57pm The existence of autoantibodies in scleroderma was described more than 40 years ago. Indeed, such autoantibodies, some highly disease-specific, are present in virtually all patients with scleroderma. Although the important autoantibodies are directed against nuclear components, it is clear that most patients with scleroderma also have antibodie ... Read on »
Potential roles of autoantibodies in systemic sclerosis. by Jan Posted Fri 11 Sep 2009 4:58pm Novel Phenotypic Associations of Scleroderma Autoantibodies Researchers are continuing to observe new associations of SSc-specific antibodies with specific clinical phenotypes. In particular, autoantibodies to several nucleolar antigens have emerged as novel diagnostic and/or predictive markers of lung involvement in SSc. Read More....... ... Read on »
Systemic sclerosis: an autoantibody mosaic by Jan Posted Fri 11 Sep 2009 4:55pm Research by C C Bunn and C M Black Systemic sclerosis (SSc) is a disease characterized by collagen deposition and subsequent fibrosis in skin and internal organs. The extent of fibrosis shows considerable variation in severity, leading to a classification that divides the disease into two main categories: the limited cutaneous form, primaril ... Read on »
Novel Autoantibody to Cu/Zn Superoxide Dismutase in Patients with Localized Scleroderma by Jan Posted Fri 11 Sep 2009 4:56pm By Masaki Nagai and Colleague Abnormal production of reactive oxygen species (ROS) induces tissue damage and superoxide dismutase (SOD) that converts superoxide radicals to hydrogen peroxide functions as defense against ROS. Cu/Zn SOD administration has been shown to be effective for various fibrotic conditions by inhibiting the fibrogenic e ... Read on »
Autoantibodies from mice exposed to Libby amphibole asbestos bind SSA/Ro52 – enriched apoptotic blebs of murine macrophage by Jan Posted Fri 11 Sep 2009 4:56pm By David J. Blake, Scott A. Wetzel, and Jean C. Pfau Asbestos exposure is associated with increased autoimmune responses in humans. For example, in Libby, MT where significant asbestos exposure has occurred due to an asbestos contaminated vermiculite mine near the community, residents have developed increased autoimmune responses compared to ... Read on »
Pathogenic autoantibodies in systemic sclerosis by Jan Posted Fri 11 Sep 2009 4:56pm By Armando Gabrielli and Colleague Systemic sclerosis, scleroderma, is a disease characterized by widespread vascular injury and fibrosis of the skin and visceral organs. Circulating autoantibodies against several intracellular antigens are common in scleroderma patients. The specificities of such autoantibodies correlate with distinct clin ... Read on »
Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis. by Jan Posted Fri 30 Oct 2009 11:02pm By Jean-François Classen and Colleague OBJECTIVE: Systemic sclerosis (SSc) is a severe connective tissue disease of unknown etiology, characterized by fibrosis of the skin and multiple internal organs. Recent findings suggested that the disease is driven by stimulatory autoantibodies to platelet-derived growth factor receptor (PDGFR), which ... Read on »