Autoantibodies

Update on autoantibodies in systemic sclerosis by Jan Posted Thu 12 Nov 2009 10:03pm By Walker, Jennifer G; Fritzler, Marvin J Purpose of review: This is a review of autoantibodies described in systemic sclerosis with an emphasis on recently published studies. In the past, most, if not all of the discussion on this topic focused on antinuclear antibodies, but it is now appreciated that autoantibodies to cytoplasmic, cell surface Read on »

Pathogenic autoantibodies in systemic sclerosis by Jan Posted Fri 11 Sep 2009 4:56pm . Circulating autoantibodies against several intracellular antigens are common in scleroderma patients. The specificities of such autoantibodies correlate with distinct clinical manifestations. However, till date there is no evidence that these autoantibodies, though helpful in diagnosis and prognosis, are linked to the pathogenesis of scleroderma nor Read on »

Autoantibodies as predictive tools in systemic sclerosis. by Jan Posted Sun 07 Feb 2010 12:00am Nat Rev Rheumatol. 2010 Feb;6(2):112-6. The pathogenetic role of autoantibodies in systemic sclerosis (SSc) remains unclear, but these autoantibodies have been... autoantibody-anti-centromere antibodies, anti-topoisomerase antibodies and anti-RNA polymerase III antibodies-are found in over 50% of patients; the presence of each is generally Read on »

Role of sodium silicate in induction of scleroderma-related autoantibodies in brown Norway rats through oral and subcutaneous ad by Jan Posted Wed 24 Feb 2010 12:00am Rheumatol Int. 2010 Jan 5. Role of sodium silicate in induction of scleroderma-related autoantibodies in brown Norway rats through oral and subcutaneous administration... in a dose of 3 mg in 0.2 ml NS was administered through oral and subcutaneous routes to 20 brown Norway rats. Autoantibodies including ANA, anti-RNP, anti-SCL70 and anti-centromere Read on »

Autoantibodies against PDGF Receptor in Scleroderma by Filemon K. Tan by Jan Posted Fri 11 Sep 2009 4:57pm The existence of autoantibodies in scleroderma was described more than 40 years ago. Indeed, such autoantibodies, some highly disease-specific, are present in virtually all patients with scleroderma. Although the important autoantibodies are directed against nuclear components, it is clear that most patients with scleroderma also have antibodies against Read on »

Autoantibody and idiotype profile of lung involvement in autoimmune rheumatic disease by Jan Posted Thu 12 Nov 2009 10:03pm By Jones, M. and Colleague Autoimmunity occurs when antibodies, known as autoantibodies, are made against bodily tissues that should not be recognized as foreign. Autoantibodies that are specific to certain types of cells have been found to be associated with particular symptoms of autoimmune disease, such as lung involvement. A study Read on »

Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis. by Jan Posted Fri 30 Oct 2009 11:02pm and multiple internal organs. Recent findings suggested that the disease is driven by stimulatory autoantibodies to platelet-derived growth factor receptor (PDGFR), which stimulate... for antinuclear autoantibodies, but did not specifically activate PDGFRalpha or PDGFRbeta in any of the tests. Cell stimulation with PDGF itself consistently produced a strong signal Read on »

Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis. by Jan Posted Wed 04 Nov 2009 10:07pm of the skin and multiple internal organs. Recent findings suggested that the disease is driven by stimulatory autoantibodies to platelet-derived growth factor receptor (PDGFR), which... positive when tested for antinuclear autoantibodies, but did not specifically activate PDGFRalpha or PDGFRbeta in any of the tests. Cell stimulation with PDGF itself consistently Read on »

Potential roles of autoantibodies in systemic sclerosis. by Jan Posted Fri 11 Sep 2009 4:58pm Novel Phenotypic Associations of Scleroderma Autoantibodies Researchers are continuing to observe new associations of SSc-specific antibodies with specific clinical phenotypes. In particular, autoantibodies to several nucleolar antigens have emerged as novel diagnostic and/or predictive markers of lung involvement in SSc. Read More Read on »

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