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Angiotensin Inhibition - Articles

Brown rice, cardiovascular protection, and angiotensin II by Dr. John Z. Medical Doctor Posted Thu 29 Apr 2010 12:00am angiotensin II. Angiotensin II is an endocrine protein and a known culprit in the development of high blood pressure and atherosclerosis. Considering this angiotensin II inhibition, brown rice may ultimately become known as a functional food for people at risk for high blood pressure. Brown Rice and Angiotensin II Inhibition The subaleurone layer Read on »
Basic Review: The Renin-Angiotensin-Aldosterone Axis by Matt S. Posted Thu 27 Aug 2009 12:00am One of the coolest aspects of the renin-angiotensin-aldosterone system (RAAS) is that it involves multiple organ systems: the liver, lung, adrenal gland, kidney... with thus far promising results. 2. Angiotensinogen--which is synthesized and secreted from the liver--is cleaved by renin in the systemic circulation to form angiotensin I Read on »
A trap for angiotensin type 1 receptors by Matt S. Posted Sat 13 Mar 2010 12:00am The renin-angiotensin system is powerful regulator of blood pressure homeostasis. An article published in the March 24 issue of JASN highlights an emerging area of research into the modulation of AT1 receptors on different tissues. The majority of well-known angiotensin II actions are mediated via AT1 receptor stimulation, and angiotensin Read on »
Angiotensin-converting enzyme in systemic sclerosis: from endothelial injury to a genetic polymorphism. by Jan Posted Fri 11 Sep 2009 4:55pm related to angiotensin II, the final product of the renin-angiotensin system (RAS), play a role as regulators of endothelial cell function. Angiotensin-converting enzyme (ACE), the key enzyme in the RAS, is the predominant pathway of angiotensin II formation in blood and tissues. In intron 16 of the gene encoding for ACE an insertion/deletion (I/D Read on »
Angiotensin receptor blocker candesartan helps prevent diabetic retina problems by Dr. John Z. Medical Doctor Posted Tue 02 Mar 2010 12:00am - angiotensin receptor blockers - may be useful in preventing and treating diabetic retinopathy, the leading cause of vision loss in people with diabetes. The study, the largest to date... inhibitors and angiotensin receptor blockers (ARBs), may help prevent the condition. The scientists analyzed proteins from the retinas laboratory mice with normal blood pressure Read on »
Key to angiotensin formation solved? Preeclampsia linked to oxidative stress by Matt S. Posted Fri 08 Oct 2010 1:00am Researchers from the UK published a new and exciting article exploring one of the fundamental mechanisms of blood pressure regulation by the renin-angiotensin-system (RAS... here for a review of the RAS from Nate). The first step of this process is the cleavage of angiotensinogen by the enzyme renin to form angiotensin I (Ang I). Precisely how renin Read on »
Angiotensin-Receptor Blocker of ... by Dr. Rubens D. Medical Doctor Posted Sat 15 Nov 2008 7:54pm Angiotensin-Receptor Blocker of No Benefit in Patients with Heart Failure, Preserved Systolic Function 16 nov 2008--The angiotensin-receptor blocker irbesartan does... in patients with heart failure and preserved systolic function. There is currently no indication for an angiotensin-receptor blocker in these patients." LINK(S): NEJM article Read on »
Pre operative angiotensin converting enzyme inhibitor therapy increases mortality after coronary artery bypass grafting by David Smith, MD Posted Thu 11 Mar 2010 12:00am Dr. Savino calls our attention to this article by Miceli et al: This study evaluates the effect of pre-operative angiotensin-converting enzyme inhibitor (ACEI... with ACEI is associated with an increased risk of mortality, use of inotropic support, PRD, and new onset of post-operative AF. (Miceli A et al:  Effects of angiotensin converting Read on »
Angiotensin Receptor Blockers (ARBs): Ongoing Safety Review for Cancer Risk by FDA Posted Thu 15 Jul 2010 11:10am [Posted 07/15/2010] AUDIENCE: Cardiology, Oncology, Family Practice ISSUE: A recently published study - a meta-analysis combining cancer-related findings from several clinical trials - suggested use of ARBs may be associated with a small increased risk of cancer. BACKGROUND: ARBs are used in patients with high ... Read on »
PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation by Jan Posted Thu 25 Nov 2010 3:19am by phosphodiesterase type 5 (PDE5) inhibition to improve pulmonary vascular remodeling and right ventricular function. Intratracheal bleomycin (4 U/kg) or saline control was administered... inhibition ameliorates RV hypertrophy and pulmonary fibrosis associated with intratracheal bleomycin in a manner that is associated with improved NOS coupling and a reduction Read on »