Angiotensin Converting Enzyme - Articles

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Angiotensin-converting enzyme in systemic sclerosis: from endothelial injury to a genetic polymorphism. by Jan Posted Fri 11 Sep 2009 4:55pm related to angiotensin II, the final product of the renin-angiotensin system (RAS), play a role as regulators of endothelial cell function. Angiotensin-converting enzyme (ACE), the key enzyme in the RAS, is the predominant pathway of angiotensin II formation in blood and tissues. In intron 16 of the gene encoding for ACE an insertion/deletion (I/D Read on »

Pre operative angiotensin converting enzyme inhibitor therapy increases mortality after coronary artery bypass grafting by David Smith, MD Posted Thu 11 Mar 2010 12:00am Dr. Savino calls our attention to this article by Miceli et al: This study evaluates the effect of pre-operative angiotensin-converting enzyme inhibitor (ACEI... with ACEI is associated with an increased risk of mortality, use of inotropic support, PRD, and new onset of post-operative AF. (Miceli A et al: Effects of angiotensin converting Read on »

A trap for angiotensin type 1 receptors by Matt S. Posted Sat 13 Mar 2010 12:00am converting enzyme inhibitors (ACEi) and AT1 receptor blockers (ARBs) have been widely used as antihypertensive agents with cardiovascular protective effects. Elucidating factors... The renin-angiotensin system is powerful regulator of blood pressure homeostasis. An article published in the March 24 issue of JASN highlights an emerging area Read on »

Basic Review: The Renin-Angiotensin-Aldosterone Axis by Matt S. Posted Thu 27 Aug 2009 12:00am . Angiotensin I is cleaved to form angiotensin II by angiotensin converting enzyme (ACE), which is found predominantly within lung endothelium. ACE-inhibitors, as their name implies, targets the ACE enzyme and is one of the most potent anti-hypertensives (and GFR-preserving) therapies available. Angiotensin II has the following physiologic effects, which Read on »

Key to angiotensin formation solved? Preeclampsia linked to oxidative stress by Matt S. Posted Fri 08 Oct 2010 1:00am here for a review of the RAS from Nate). The first step of this process is the cleavage of angiotensinogen by the enzyme renin to form angiotensin I (Ang I). Precisely how renin... Researchers from the UK published a new and exciting article exploring one of the fundamental mechanisms of blood pressure regulation by the renin-angiotensin-system (RAS Read on »

Angiotensin receptor blocker candesartan helps prevent diabetic retina problems by Dr. John Z. Medical Doctor

Posted Tue 02 Mar 2010 12:00am - angiotensin receptor blockers - may be useful in preventing and treating diabetic retinopathy, the leading cause of vision loss in people with diabetes. The study, the largest to date... inhibitors and angiotensin receptor blockers (ARBs), may help prevent the condition. The scientists analyzed proteins from the retinas laboratory mice with normal blood pressure Read on »

Angiotensin-Receptor Blocker of ... by Dr. Rubens D. Medical Doctor

Posted Sat 15 Nov 2008 7:54pm Angiotensin-Receptor Blocker of No Benefit in Patients with Heart Failure, Preserved Systolic Function 16 nov 2008--The angiotensin-receptor blocker irbesartan does... in patients with heart failure and preserved systolic function. There is currently no indication for an angiotensin-receptor blocker in these patients." LINK(S): NEJM article Read on »

Brown rice, cardiovascular protection, and angiotensin II by Dr. John Z. Medical Doctor

Posted Thu 29 Apr 2010 12:00am angiotensin II. Angiotensin II is an endocrine protein and a known culprit in the development of high blood pressure and atherosclerosis. Considering this angiotensin II inhibition, brown rice may ultimately become known as a functional food for people at risk for high blood pressure. Brown Rice and Angiotensin II Inhibition The subaleurone layer Read on »

Angiotensin Receptor Blockers (ARBs): Ongoing Safety Review for Cancer Risk by FDA Posted Thu 15 Jul 2010 11:10am [Posted 07/15/2010] AUDIENCE: Cardiology, Oncology, Family Practice ISSUE: A recently published study - a meta-analysis combining cancer-related findings from several clinical trials - suggested use of ARBs may be associated with a small increased risk of cancer. BACKGROUND: ARBs are used in patients with high ... Read on »

An unusual cause of acute renal failure in systemic sclerosis by Jan Posted Fri 11 Sep 2009 4:56pm . -------------------------------------------------------------------------------- Keywords: scleroderma; enteric hyperoxaluria; angiotensin converting enzyme inhibitor; oxalate nephropathy; diuretics Abbreviations: ACE, angiotensin converting enzyme; SRC Read on »