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Androgen Receptor - Articles

Breast Cancer Survival Altered by Androgen Receptors by Aaron Tabor Medical Doctor Posted Fri 18 Feb 2011 10:05am Research studies have clearly shown us that androgen receptors are frequently found in breast cancer tumors .  However the impact of androgen receptors on breast cancer is still uncertain.  One study has suggested that androgen receptors might improve breast cancer outcomes in patients with estrogen receptor-positive (ER[+]) breast cancer Read on »
Overexpression of Androgen Receptors and Tamoxifen Resistance by Aaron Tabor Medical Doctor Posted Thu 06 May 2010 7:20am 2 Comments and HER2 receptors most frequently, androgen receptors have also been shown to be present in breast cancer tissues.  While the role of androgen receptors in breast cancer is still uncertain, some early studies have shown that androgen receptor expression might be associated with better breast cancer outcomes , something I've blogged about before .  However Read on »
Androgen Receptor Expression Impacts Breast Cancer Outcomes by Aaron Tabor Medical Doctor Posted Mon 15 Feb 2010 6:43am research indicates that the expression of androgen receptors in some breast cancer patients can impact breast cancer outcomes.  In this new studybreast cancer researchers explored the relationship between androgen receptor expression and breast cancer outcomes in estrogen receptor-positive (ER+) breast cancer patients with or without chemotherapy.  Analysis Read on »
First androgen receptor mRNA antagonist enters clinical trials for CRPC by Dr. Arnon Krongrad Medical Doctor Posted Wed 12 Jan 2011 12:00am , believed to be the first androgen receptor messenger RNA (mRNA) antagonist, for the treatment of patients with castration-resistant prostate cancer (CRPC). What’s special about EZN-4176? Enzon claims that it is actually able to eliminate the androgen receptors from prostate cancer cells, thereby down-regulating (shutting down) cell proliferation as opposed Read on »
Androgen Receptor Expression in Women and its Relationship to Sexual Function by Dr. Jennifer Berman Medical Doctor Posted Sat 13 Sep 2008 4:04am of androgens in women throughout the reproductive cycle. The pathophysiologic mechanism of androgen receptor expression has been documented in numerous tissue sites including the central... and estrogens on androgen bioavailability, as well as the psychophysiologic role of androgen receptor expression on sexual function demands further research to better define treatment Read on »
Protein that suppresses androgen ... by Dr. Rubens D. Medical Doctor Posted Wed 20 May 2009 10:35pm Protein that suppresses androgen receptors could improve prostate cancer diagnosis, treatment AUGUSTA, Ga., 21 may 2009 – A protein that helps regulate expression of androgen receptors could prove a new focal point for staging and treating testosterone-fueled prostate cancer, Medical College of Georgia researchers say. Levels of the protein Read on »
What’s “bipolar” androgen therapy? How does it work? by Dr. Arnon Krongrad Medical Doctor Posted Wed 28 Jul 2010 12:00am levels of androgens affect the DNA of cells that express high levels of specific androgne receptors. One such recently described effect might be the way in which androgens can... their androgen receptor expression to the environmental conditions in the body. Denmeade and Isaacs state that, “The goal is to determine if a clinical response can be achieved through Read on »
Management of advanced prostate cancer: can we improve on androgen deprivation therapy? by Dr. Arnon Krongrad Medical Doctor Posted Mon 29 Sep 2008 5:55pm of hormonal therapy compared to earlier LHRH (or GnRH) agonists. So here’s the thing. The classic androgen suppressors (Lupron/leuprolide acetate and Zoladex/goserelin acetate, as well as a couple of less commonly used agents) are what is known as LHRH (or GnRH) receptor ”agonists.” They are synthetic analogs of luteinizing hormone releasing hormone Read on »
Bone loss after androgen deprivation for prostate cancer by Dr. Arnon Krongrad Medical Doctor Posted Wed 17 Sep 2008 2:00pm and upon which prostate cancer often depends. Because testosterone falls into a class of hormones known as androgens, prostate cancer treatments that negate its effects are referred to as anti-androgens (AAs) or androgen deprivation treatments (ADTs). Surgical castration is permanent, relatively cheap, and safe. However, it’s not very appealing to most men Read on »
Androgens for anemia by Mark Levin Posted Fri 16 Jul 2010 11:13am Androgen therapy is well established for anemia due to underproduction. Various androgens have been studied and the literature is now old, with most studies being in the 1970s and 19080s. The combination of an androgen and a corticosteroid reduces anemia in one third of patients with aplastic anemia. Androgens are also effective for anemia Read on »