Alzheimer's-causing Amyloid and Bacteria Trigger Same Immune Response in the Brain
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CherylPosted
Mon 27 Jul 2009 11:53pm
, secondary amyloidosis and prion diseases, like Creutzfeldt-Jakob (the human form of mad cow disease). These diseases all involve marked inflammation at the sites of amyloiddeposition, resulting in tissue injury.
The protein forming plaques in Alzheimer’s patients is normally soluble. When the protein folds improperly, it forms amyloiddepositsRead on »
Serum Amyloid P prevents renal fibrosis
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Matt S.Posted
Fri 06 Nov 2009 12:00am
clinically to identify sites of amyloiddeposition in systemic amyloidosis. In the studies, hSAP was given to mice with either unilateral ureteric obstruction or unilateral ischemia...
Congratulations to my colleague at the Brigham, Jeremy Duffield, who made the cover of Science this week for demonstrating human Serum Amyloid P (hSAP
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Beta-Amyloid and Alzheimer's
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Krista H.Posted
Thu 13 Aug 2009 7:51pm
I was reading an article online that talks about the Alzheimer's-related protein known as beta-amyloid.
Beta-amyloid is best known as the sticky goo that makes up the hallmark plaques inside the brains of Alzheimer's victims. But it doesn't start out as gunk. Soluble forms are found in the fluid that bathes the brain, although scientists don't
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Beta-Amyloid PET Imaging Agents
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nih.govPosted
Sun 13 Jun 2010 5:00pm
) a new method of synthesizing the IMPY derivatives, using palladium as a catalyst, 2) methods of imaging beta-amyloiddeposits in the brain by in vivo PET, magnetic resonance...-amyloid peptides and plaques in humans.
Beta-amyloid peptide deposition in the brain is a pathological feature of Alzheimer’s disease (AD). Early detection of beta-amyloidRead on »
Medivation Dimebolin (Dimebon) Increases Brain Beta Amyloid in Alzheimer's Models
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Bob DeMarcoPosted
Wed 15 Jul 2009 6:56pm
to Alzheimer's disease.
Beta amyloid is a protein that is the main constituent of amyloid plaques found in the brains of people with Alzheimer's disease. It is widely considered a key... dimebolin affects beta amyloid levels in the brain."
"A number of ideas need to be pursued. It may turn out that the drug works by getting toxic amyloid out of brain nerve cells
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Use of AmyloidProteins as Vaccine Scaffolds
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nih.govPosted
Sun 13 Jun 2010 5:00pm
Description of Invention:
Amyloidproteins are composed of peptides whose chemical properties are such that they spontaneously aggregate in vitro or in vivo, assuming parallel or antiparallel beta sheet configurations. Amyloidproteins can arise from peptides which, though differing in primary amino acid sequences, assume the same
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Beta-Amyloid Clearance from Brain May Underly Alzheimer’s Disease
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MedNewsPosted
Thu 09 Dec 2010 2:36pm
of dementia in older adults, and affects as many as 5.1 million Americans. In Alzheimer’s disease, a protein fragment called beta-amyloid accumulates at abnormally high levels...’s disease, beta-amyloid is produced in the brain at a normal rate but is not cleared, or removed from the brain, efficiently.
In addition to improving the understanding of what
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