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Antioxidant Therapy for Scleroderma

Posted Sep 09 2009 7:43pm 3 Comments

Welcome to my blog, which want to share the experience about the antioxidant therapy for scleroderma patient. Last four years, my mother got scleroderma disease and I found that antioxidant therapy could help her get well.

Firstly, I would like to introduce you to know more about scleroderma disease. Scleroderma or systemic sclerosis is autoimmune disease that means the immune cells treat normal cells, especially collagen - producing cells of connective tissue, as the foreign cells. This even occurs when free radicals are abnormal accumulated in the body by oxidative stress. The abnormal accumulation of free radicals and metals such as iron activates activity of propyl hydroxylase, which is the collagen-producing enzyme, to increase overproduction of collagen. The excessive collagen deposition leads to fibrosis of connective tissue.  This fibrosis occurs not only at the skin but also at the internal organs such as heart, lungs, kidneys, gastrointestinal tract, muscles, and joints. 

Moreover, oxygen free radicals are the important initiators of tissue damage in scleroderma. There is the research show that the immune cells of scleroderma patient release the excess level of superoxide anion, which is the one type of oxygen free radical. This superoxide anion can react with nitric oxide, which is the most potent endogenous vasodilator, leading to increase toxic free radical called peroxynitrite.
The event that I mention above causes tissues damage and cells death with changed molecules, so the immune system treats them as foreign invaders. 

The first actually symptom of scleroderma is Raynaud’s phenomenon with abnormal sensitivity to cold in the hands or feet.  Other symptoms may include one or more are swelling of the fingers, hands, feet, lower legs and face, hardening and thickening of the skin, shortness of breath, cough, digestive and gastrointestinal problems such as difficulty swallowing and bloating. In the case of my mother, doctor found fibrous connective tissue at her heart and lungs. Therefore, the most serious condition that she had is heart failure.

As I tell you earlier that my mother got scleroderma for two years. The first year, I treat her only the medicines that received from doctor. The second year, I had read that the increase level of free radicals and the decrease level of antioxidant such as vitamin C, vitamin E and beta-carotene are the main cause of scleroderma. Therefore, antioxidant therapy is used. The first course, I treat my mother with vitamin C, vitamin E, beta-carotene, co enzyme Q10, and fish oil. After that, when I read more and found that superoxide anion and nitric oxide are the key free radical for scleroderma, so bioflavonoid is use for neutralized superoxide anion and optimized nitric oxide activity.    

Now, I still treat my mother with antioxidant because she is very well when comparing with medicinal treatment only.

Comments (3)
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According to my latest post about Antioxidant therapy for scleroderma,  there're some interested references.


Cerinic, M.M. and M.B. Kahaleh.  20002. <a href="">Beauty and the beast. The nitric oxide
paradox in systemic  sclerosis</a>.  Rheumatology.

Denton, C. P. 2002. Systemic sclerosis.

Dooley, A. and others.  2006. Abnormal nitric oxide metabolism in systemic sclerosis increased levels of nitrated protein and asymmetric dimethylarginine. Rheumatology.

Mok, M.Y. and others. 2007. Serum nitric oxide metabolites and disease activity n patients with systemic sclerosis. Clinical Rheumatology.

Sambo, P. and others. 1999. Monocytes of patients with systemic sclerosis (scleroderma) spontaneously release in vitro increased amount of superoxide anion. The Journal of  Investigative Dermatology.

GoooooD luck 4 fighting with scleroderma^^





 I have a brother who has MS, I know that isn't scleroderma, but from your descrition of scleroderma, some of the problems and symptoms are similar.  I've found a product with an extremely high ORAC value (15,000 ORAC units per gram).  I've started my brother on this product with hopes that it will help his MS, since all previous therapy's have had no positive results. I'm curious on your thoughts about this.  Please email me at




Dear Tim,

I have read about MS. It's an autoimmune disorder as same as scleroderma.

For my mother's case, I treat her with antioxidants  such as bioflavonoid, omega-3 and Co q10 only first 2 years (together with med from doctor). After that, I try to treat her with antioxidant food from fresh veg. and fruits^^

 Now, confirm by blood test and doctor, my mother gets well and healthy.

I hope ur brother will get well soon from MS......and both of u have a happy life~^^~

pls. visit my mother's blog...:

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