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what are the 2 most commonly used antihistamines for anxiety?

Posted by amina6ae

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Ian Health Maven

Many antidepressants have strong antihistamine properties, especially the tricyclics, so they would probably be at the top of the list.

Diphenhydramine (Benadryl) is sometimes used for anxiety and depression, but the antidepressant effect is mild and anxiety relief probably is due more to sedation than inhibition of serotonin reuptake. However, sedation is relatively short-lived - as little as 3-4 days - thereafter it mostly relies on the placebo effect. Chlorpheniramine is another antihistamine sometimes used to treat anxiety. If you have mild anxiety then these may be worth trying, but IMHO, cognitive behavior therapy would be better.

Best wishes


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